Robert Witt – Newark DE

4745 Ogletown-Stanton Rd
MAP #1, #112
Newark, DE 19713
Germany
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302 738 6014

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1. Professor: Otolaryngology-Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA
2. Affiliate Professor: Biological Sciences, University of Delaware, Newark DE
3. Director of the Head and Neck Multi-Disciplinary Center, Helen F. Graham Cancer Center, Christiana Care, Newark, DE, USA
4. Principal Investigator (R01 grant)- National Institute of Health (NIH) Grant-
Functional Assembly of Salivary Cells to Relieve Xerostomia
5. Editor of three books (Thyroid Cancer, Salivary Gland Diseases).
6. Authored more than 75 manuscripts and chapters (most as first author)
7. Speaker, panelist, and moderator at many international meetings.
8. Editorial board member of leading journals.
9. Opera and Art Song Tenor Soloist.
10. Fluent in German

(1) Schuknecht H, Witt R. Suppressed Sneezing as a Cause of Hearing
Loss and Vertigo. American Journal of Otolaryngology
1985;6:468-470.
(2) Schuknecht H, Witt R. Acute Bilateral Sequential Vestibular
Neuritis. American Journal of Otolaryngology 1985;6:255-
257.
(3) Witt R. Otitis Media: An Overview of Current Treatment
Delaware Medical Journal 1988;60:69-71.
(4) Witt R. The Tonsil and Adenoid Controversy. Delaware Medical
Journal 1989;61:289-293.
(5) Witt R. Management of Adenoid Cystic Carcinoma of the
Minor Salivary Glands. Ear, Nose and Throat Journal
1991;70:218-222.
(6) Witt R. Failure of Radiation Therapy in Stage I and II Glottic
Squamous Cell Carcinoma. Delaware Medical Journal
1995;67:430-435.
(7) Witt R. Primary Small Cell Carcinoma of the Parotid.
Otolaryngology – Head and Neck Surgery 1996;114:826-
829.
(8) Witt R. Facial Nerve Monitoring in Parotid Surgery. Is it the
Standard of Care? Otolaryngology - Head and Neck Surgery
1998;119:468-470.
(9) Witt R. Facial Nerve Function After Partial Superficial
Parotidectomy. Otolaryngology - Head and Neck Surgery
1999;121:210-213.
(10) Witt R. The Significance of Margin in Surgery for Parotid
Pleomorphic Adenoma. Laryngoscope 2002;112:2141-
2154.
(11) Witt R. Prognostic Factors in Mortality and Morbidity in
Differentiated Thyroid Cancer. Ear Nose & Throat
2002;12:856-863.
(12) Witt R. Colonic Adenocarcinoma Metastatic to Thyroid Hurthle Cell
Carcinoma Presenting with Airway Obstruction Del Med J
2003;75:285-288.
(13) Witt R. Sarcoidosis Presenting as Bilateral Vocal Cord Paralysis.
Journal of Voice 2003;2:265-268.
(14) Witt R. Head and Neck Cancer Care in the State of Delaware-The
Advent of the Helen F. Graham Head and Neck Cancer
Center. Delaware Med J 2003;75:455-459.
(15) Witt R. Electrophysiologic Monitoring of the Recurrent Laryngeal
Nerves may not Predict Bilateral Vocal Fold Immobility
after Thyroid Surgery. J Voice 2004;18/2:255-259.
(16) Witt R. A comparison of the results of monolayer versus smear
cytopreparatory techniques for fine-needle aspiration in 100
consecutive patients undergoing thyroidectomy: A surgeon’s
perspective. Otolaryngol Head Neck Surg 2004;131(6):964-67.
(17) Witt R, Weinstein G, Rejto L. Tympanomastoid Suture and
Digastric in Cadaver and Live Parotidectomy. Laryngoscope 2005;115:574- 77.
(18) Witt R. Minimally invasive surgery for parotid pleomorphic
adenoma. ENT J. 2005;84(5):308-11.
(19) Witt R. Electrophysiologic Monitoring in Thyroid Surgery: The
Standard of Care? J Voice. 2005;19(3):497-500.
(20) Witt R. Head and Neck Cancer Care at a Community Based Teaching
Hospital. Head Neck. 2005;27(7):613-5.
(21) Witt R. Gillis G, Pratt R. Spinal accessory nerve monitoring with clinical
outcome measures. ENT J, 2006;85(8):540-544.
(22) Witt R. Comparing the long term outcome of immediate post-operative facial
nerve dysfunction and vocal fold immobility after parotid and thyroid surgery. J Voice. 2006;20(3):461-464.
(23) Witt R., Rejto L. Spinal Accessory Nerve Monitoring in Selective and
Modified Neck Dissection Laryngoscope 2007;117(5):776-780.
(24) Witt R, Rejto L. Pleomorphic adenoma: Extracapsular Dissection versus Partial Superficial Parotidectomy with facial nerve dissection. Del Med J, 2009; 81(3):119-125.
(25) Witt R. Wilson P. Vocal fold immobility from primary minor salivary gland
small cell carcinoma. ENT J 2009;88(2):E13-16.
(26) Witt R, Wilson P Missed opportunity for larynx preservation? Failure to
distinguish verrucous and squamous cell carcinoma on
microlaryngoscopy and biopsy. J Voice 2009;23(1):140-142.
(27) Witt R. Sialendoscopy in Delaware. Del Med J, 2009;81(6)227-29.
(28) Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A.
Freedom from local and regional failure of the contralateral neck with
ipsilateral neck radiation therapy for N+ Tonsil Cancer: Results of a prospective management approach. Rad Onc Bio Physics. 2009;74(5):1365-70.
(29) Witt R. The Incidence and Management of Siaolocele Post-Parotidectomy.
Otolaryngol-Head Neck Surg 2009 140,871-74.
(30) Pradhan-Bhatt, S, Zhang C, Jia X, Carson D, Witt R, Farach-Carson MC.
Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro. Tissue Engineering 2009;15(11):3309-3320.
(31) Witt R, Wilson P. Surgery After Cocaine Ingestion. ENT J, 2010;89(2):E14
16.
(32) Swati P, Liu Chao, Zhang C, Jia Xinqiao, Farach-Carson, Witt R. Lumen
formation in 3D cultures of salivary acinar cells. Otolaryngology-Head & Neck Surg 2010;142:195-195
(33) Witt R. What is the treatment of the lateral neck in clinically localized sporadic medullary thyroid cancer Laryngoscope 2010;120(7):1286-87.
(34) Witt R. What is the Best Practice for Benign Mixed Tumor 2011 DE Med J;83(6):175-6.
(35) Witt R. Iro H, Koch M, McGurk M, Nahlieil O, Zenk J. Contemporary Review: Minimally Invasive Options for Salivary Calculi. Laryngoscope 2012;122:1306-1311.
(36) Witt R, Iacocca M. Comparing capsule exposure using extracapsular dissection with partial superficial parotidectomy for pleomorphic adenoma. Amer J Otolaryngol 2012;33(5):581-4.
(37) Zbaren P, Vander Poorten V, Witt RL, et al. Pleomorphic Adenoma of the Parotid: Formal Parotidectomy or Limited Surgery Am J Surg 2013; 205: 109-118.
(38) Witt R, Ferris R, Pribitkin E, Sherman S, Steward D, Nikiforov, Y. Diagnosis and Management of Differentiated Thyroid Cancer using Molecular Biology. Laryngoscope 2013;123:1059-1064.
(39) Witt R, Pribitkin E. How can Frey’s syndrome be prevented or treated following parotid surgery. Laryngoscope 2013;123:1573-74.
(40) Pradhan-Bhatt S, Harrington D, Duncan R, Jia X, Witt R, Farach-Carson C. Implantable Three-Dimensional Salivary Spheroid Assemblies Demonstrate Fluid and Protein Secretory Responses to Neurotransmitters. Tissue Engineering 2013;Vol 19, #13,14, Part A:1610-20. (Cover of Journal, Figure from Journal.)
(41) Lombaert IMA, Abrams SR, Li L. Eswarakumar VP, Sethi AJ, Witt, RL, Hoffman MP. Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013;1:604-19.
(42) Pradhan-Bhatt S, Harrington D, Duncan R, Farach-Carson M, Xia J, Witt R. A Novel In Vivo Model for Evaluating Functional Restoration of a Tissue Engineered Salivary Gland Laryngoscope 2014;124:456-61.
(43) Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X. Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions. Acta Biomaterilalia. 2014;10:1558-70.
(44) Condamine T, Witt, RL, Gabrilovich I. et al. ER stress response regulates
the fate of myeloid-derived suppressor cells through TRAIL receptors mediated apoptosis in cancer. J Clin Invest. 2014 Jun 2;124(6):2626-39.
(45) Witt RL, Gerges F, Iacocca M. Contemporary Diagnosis and Management of Warthin’s Tumor. De Med J 2014;87(1):13-16.
(46) Witt RL, Eisele D, Morton R. et al. Etiology and Management of Recurrent Parotid Pleomorphic Adenoma. Laryngoscope 2015;125(4):888-893.
(47) Witt RL, Sukumar VR, Gerges F. Surgeon Performed Ultrasound Guided FNAC with On-Site Cytopathology improves adequacy and accuracy. Laryngoscope. 2015;125(7) 1633-6. DOI: 10.1002/lary.25214
(48) Dan TD, Raben A, Witt RL. Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: Updated results of an institutional clinical management approach. Oral Oncol 2015 doi: 10.1016/j.oraloncology.2015.03.013
(49) Witt RL. Outcome of Thyroid Gene Expression Classifier Testing in Clinical Practice. Laryngoscope. 2016;126:524-27.
(50) Witt, RL. Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors. Otolaryngology-Head & Neck Surg. 2016;154(3):572-74.
(51) Ozdemir T, Fowler E, Hao Y, Ravikrishnan A, Harrington D, Witt, R, Farach-Carson, M, Pradhan-Bhatt S, Jia X. Biomaterials based strategies for salivary gland tissue regeneration. Biomaterials Science 2016;4:592-604.
(52) Witt RL. What is the Best Management of Incidental Papillary Thyroid Microcarcinoma? Laryngoscope. 2016;126(10) 2203-4.
(53) Srinivasan P, Witt, R, Pradhan-Bhatt, S, et al. Primary Salivary Human Stem/Progenitor Cells (hS/PCs) Undergo Microenvironment Driven Acinar-like Differentiation in Hyaluronate Hydrogel Culture. Stem Cells. 2017;6(1):110-120.

(54) Condamine T, Witt RL, Gabrilovich D. et al. Lectin-type oxidized LDL receptor 1 distinguishes population of human polmorphonuclear myeloid-derived suppressor cells in cancer patients. Science Immunology 2016 1(2):aaf8943
(55) Witt RL, Targeted Next Generation Sequencing with ThyroSeq v2.1 for Indeterminate Thyroid Nodules In Clinical Practice 2016. DE Med J;88(12):366-367.
(56) Tugba O, Fowler E, Witt RL, et al. Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D. ACS Biomaterials Science & Engineering. 2016 12;2(12):2217-2230. DOI: 10.1021/acsbiomaterials.6b00419
(57) Sagiv D, Witt RL, Talmi Y et al . Warthin Tumor within the Superficial Lobe of the Parotid Gland: a Suggested Criterion for Diagnosis. European Arch OtoRhinoLaryngol 2017;274(4):1993-1996.
(58) Roth MY, Witt RL, Steward DL. Molecular Testing for Thyroid Nodules: Review and Current State. Cancer 2018;124(5):888-898. DOI 10.1002/cncr.30708
(59) Witt, RL. Thyroid Molecular Testing using Ultrasound. International Journal of Head and Neck Science 2017;1(3):147-153
(60) Witt RL. Comment on: Does Mutational Analysis Influence the Management of Differentiated Thyroid Cancers? Laryngoscope 2017 DOI: 10.1002/lary.26811
(61) Ozdemir T, Srinivasan PP, Witt RL et al. Bottom-up Assembly of Salivary Gland Microtissues for Assessing Myoepithelial Cell Function. BioMaterials.2017;142:124-135 PMID: 28734180
(62) Witt R. High Thyroid Surgical Volume Compared to Intermediate Volume Reduces Vocal Fold Immobility International Journal of Head and Neck Science (in press)

(63) Condamine T, Dominguez GA, Mony S, Hashimoto A, Liu Q, Forero A, Bendell J, Witt RL, Hockstein N, Kumar P, Gabrilovich DI. Selective targeting of myeloid-derived suppressor cells in cancer patients using DS-8273a, an agonistic TRAIL-R2 antibody. Clinical Cancer Research, 2017 Jun 15;23(12):2942-2950.

(64) Palmer D, Witt RL, Raben, A. et al Combination of post-operative radiotherapy and cetuximab for high-risk cutaneous squamous cell cancer of the head and neck: A propensity score analysis. Oral Oncology 2018 (in press)