Jason Tasoulas – Philadelphia Pennsylvania

• Dentist
• Head and Neck Research
• Head and Neck Surgeon

925 Chestnust Str
6th Floor
Philadelphia, Pennsylvania 19107
United States
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I'm an incoming PGY-1 resident at the Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University. Previously, I was a Post-Doctoral Research Fellow at the Department of Otolaryngology-Head and Neck Surgery, The University of North Carolina at Chapel Hill. I have a background in medicine (MD), dentistry (DMD) and cancer biology (PhD, Post-Doc) and an interest in head and neck surgical oncology. My research interests include HPV+ HNSCC and salivary gland carcinomas, with prior work concentrating on Adenoid Cystic Carcinoma microenvironment/immune microenvironment (PhD) and HPV-mediated squamous cell carcinogenesis (Post-Doc).

1. Tasoulas J, Farquhar DR, Sheth S, Hackman T, Yarbrough WG, Agala CB, Koric A, Giraldi L, Fabianova E, Lissowska J, Świątkowska B, Vilensky M, Wünsch-Filho V, de Carvalho MB, López RVM, Holcátová I, Serraino D, Polesel J, Canova C, Richiardi L, Zevallos JP, Ness A, Pring M, Thomas SJ, Dudding T, Lee YA, Hashibe M, Boffetta P, Olshan AF, Divaris K, Amelio AL. Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis. J Natl Cancer Inst. 2024 Jan 10;116(1):105-114.
2. Sajisevi M, Nguyen K, Callas P, Holcomb AJ, Vural E, Davis KP, Thomas CM, Plonowska-Hirschfeld KA, Stein JS, Eskander A, Kakarala K, Enepekides DJ, Hier MP, Ryan WR; American Head and Neck Society Salivary Gland Section; Asarkar AA, Aulet R, Bell RK, Blasco MA, Bowmaster VB, Burruss CP, Chung J, Chan K, Chang BA, Coffey CS, Cognetti DM, Cooper DJ, Cordero J, Donovan J, Du YJ, Dundar Y, Dedivitis RA, Edwards HA, Erovic BM, Feinberg PA, Garvey EA, Goldstein DP, Goodman JF, Goulart RN, Goyal N, Grasl S, Giurintano JP, Gupta N, Habib AM, Hackman TG, Hara JH, Henson C, Hinni ML, Hua N, Johnson-Obaseki S, Juloori A, Kalman NS, Kejner AE, Khaja SF, Ku JA, Lambert A, Luu BK, Magliocca KR, Dos Santos LRM, Michael C, Miles BA, de Melo GM, Moore MG, Morand GB, Moura K, Mukdad L, Noroozi H, Patel R, Paydarfar JA, Sadeghi N, Savaria FN, Schmitt NC, Shapiro J, Shaver TB, Stoeckli SJ, St John M, Stokes WA, Sulibhavi A, Tasoulas J, Vendra V, Vinh DB, Virgen CG, Wooten C, Woody NM, Young GD. Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma. JAMA Otolaryngol Head Neck Surg. 2024 Feb 1;150(2):107-116.
3. Farquhar DR, Masood MM, Lenze NR, Tasoulas J, Sheth S, Lumley C, Blumberg J, Yarbrough WG, Zevallos J, Weissler MC, Zanation AM, Hackman TG, Olshan AF. Effect of distance of treatment center on survival for HPV-negative head and neck cancer patients. Head Neck. 2023 Dec;45(12):2981-2989.
4. Tasoulas J, Schrank TP, Smith BD, Agala CB, Kim S, Sheth S, Shen C, Yarbrough WG, Hackman T, Sullivan CB. Time to treatment patterns of head and neck cancer patients before and during the Covid-19 pandemic. Oral Oncol. 2023 Nov;146:106535. doi: 10.1016/j.oraloncology.2023.106535. Epub 2023 Aug 23. PMID: 37625360.
5. Tasoulas J, Srivastava S, Xu X, Tarasova V, Maniakas A, Karreth FA, Amelio AL. Genetically engineered mouse models of head and neck cancers. Oncogene. 2023 Jul 20.
6. Schrank TP, Kothari A, Weir WH, Stepp WH, Rehmani H, Liu X, Wang X, Sewell A, Li X, Tasoulas J, Kim S, Yarbrough G, Xie Y, Flamand Y, Marur S, Hayward MC, Wu D, Burtness B, Anderson KS, Baldwin AS, Yarbrough WG, Issaeva N. Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors. Proc Natl Acad Sci U S A (PNAS). 2023 Aug 8;120(32).
7. Lambert T, Tasoulas J, Flores M, Sheth S, Patel SN. Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma. Oral Oncol. 2023 May;140:106361.
8. Tasoulas J, Sheth S. Induction therapy in recurrent head and neck squamous cell carcinoma: is it time to consider response as a determinant of treatment selection? Transl Cancer Res. 2023 Apr 28;12(4):697-700.
9. Murphy RM, Tasoulas J, Porrello A, Carper MB, Tsai YH, Coffey AR, Kumar S, Zeng PY, Schrank TP, Midkiff BR, Cohen SM, Salazar AH, Hayward MC, Hayes DN, Olshan AF, Gupta GP, Nichols AC, Yarbrough WG, Pecot CV, Amelio AL. Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer. Cancer Research Communications. 2022 Aug 16.
10. Tasoulas J, Lenze NR, Farquhar D, P Schrank T, Shen C, Shazib MA, Singer B, Patel S, Grilley Olson JE, Hayes DN, Gulley ML, Chera BS, Hackman T, Olshan AF, Weiss J, Sheth S. The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC. Cancer Med. 2021 May;10(10):3231-3239. doi: 10.1002/cam4.3883. PMID: 33934525.
11. Tasoulas J, Divaris K, Theocharis S, Farquhar D, Shen C, Hackman T, Amelio AL. Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis. Cancers (Basel). 2021 Feb 3;13(4):589. doi: 10.3390/cancers13040589. PMID: 33546179.
12. Sharma KP, Tasoulas J, Musicant AM, Nascimento-Filho C, Zhu Z, Twomey C, Liu P, Castilho R, Amelio AL. Potent Anticancer Efficacy of the Dual EGFR and HDAC Inhibitor CUDC-101 Overcomes Tolerance to EGFR Monotherapy in Salivary Mucoepidermoid Carcinoma. Accepted, Oral Oncology.
13. Theocharis S, Tasoulas J, Masaoutis C, Kokkali S, Klijanienko J. Salivary gland cancer in the era of immunotherapy: can we exploit tumor microenvironment? Expert Opin Ther Targets. 2020 Oct;24(10):1047-1059. doi: 10.1080/14728222.2020.1804863.
14. Farquhar, D. R., Lenze, N. R., Masood, M. M., Divaris, K., Tasoulas, J., Blumberg, J., Lumley, C., Patel, S., Hackman, T., Weissler, M. C., Yarbrough, W., Zanation, A. M., & Olshan, A. F. (2020). Access to preventive care services and stage at diagnosis in head and neck cancer. Head & neck, 10.1002/hed.26326.
15. Tasoulas J, Rodon L, Kaye FJ, Montminy M, Amelio AL. Adaptive Transcriptional Responses by CRTC Coactivators in Cancer. Trends Cancer. 2019 Feb;5(2):111-127. doi: 10.1016/j.trecan.2018.12.002.
16. Tasoulas J, Tsourouflis G, Klijanienko J, Theocharis S. Polymorphous adenocarcinoma of the salivary glands: An overview of immunohistochemical features and insights on molecular pathology. Histol Histopathol. 2019 Feb 6:18089. doi: 10.14670/HH-18-089.
17. Papadiochos I, Petsinis V, Tasoulas J, Goutzanis L. Pure Orbital Trapdoor Fractures in Adults: Tight Entrapment of Perimuscular Tissue Mimicking True Muscle Incarceration with Successful Results from Early Intervention. Craniomaxillofac Trauma Reconstr. 2019 Mar;12(1):54-61. doi:10.1055/s-0038-1625965.
18. Tasoulas J, Tsourouflis G, Theocharis S. Neovascularization: an attractive but tricky target in thyroid cancer. Expert Opin Ther Targets. 2018 Sep;22(9):799-810. doi: 10.1080/14728222.2018.1513494.
19. Tzanavari T*, Tasoulas J*, Vakaki C, Mihailidou C, Tsourouflis G, Theocharis S. The role of adipokines in the establishment and progression of head and neck neoplasms. Curr Med Chem. 2018 Jul 13. *First co-author
20. Nikitakis NG, Rassidakis GZ, Tasoulas J, Gkouveris I, Kamperos G, Daskalopoulos A, Sklavounou A. Alterations in the expression of DNA damage response-related molecules in potentially preneoplastic oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):637-649.
21. Levidou G, Kotta-Loizou I, Tasoulas J, Papadopoulos T, Theocharis S. Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas. Dis Markers. 2018 Jan 28;2018:4020937.
22. Tasoulas J, Daskalopoulos A, Droukas C, Nikitakis N. An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov;122(5):525-529.
23. Titsinides S, Nikitakis NG, Tasoulas J, Daskalopoulos A, Goutzanis L, Sklavounou A. Ossifying Fibromyxoid Tumor of the Retromolar Trigone: A Case Report and Systematic Review of the Literature. Int J Surg Pathol. 2017 Apr 1:1066896917705197. doi: 10.1177/1066896917705197.
24. Theocharis S, Kotta-Loizou I, Giaginis C, Alexandrou P, Danas E, Tsourouflis G, Tsoukalas N, Coutts RH, Tasoulas J, Klijanienko J. Expression and Clinical Significance of Concomitant FAK/SRC and p-Paxillin in Mobile Tongue Squamous Cell Carcinoma. Anticancer Res. 2017 Mar;37(3):1313-1319.
25. Tasoulas J, Patsouris E, Giaginis C, Theocharis S. Salivaomics for oral diseases biomarkers detection. Expert Rev Mol Diagn. 2015 Dec 17.
26. Theocharis S, Giaginis C, Alexandrou P, Rodriguez J, Tasoulas J, Danas E, Patsouris E, Klijanienko J, Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival, Tumor Biology (2015), doi: 10.1007/s13277-015-4182-8.
27. Zanakis S, Tasoulas J, Angelidis I, Dendrinos C, Tooth in the line of angle Fractures: the impact in the healing process. A retrospective study of 112 patients, Journal of Cranio-Maxillo-Facial Surgery (2014), doi: 10.1016/j.jcms.2014.10.020.
28. Tasoulas J, Giaginis C, Patsouris E, Manolis E, Theocharis S. Histone deacetylase inhibitors in oral squamous cell carcinoma treatment. Expert Opin Investig Drugs. 2014 Sep 12:1-10.
29. Konstantinidou AE, Tasoulas J, Kallipolitis G, Gasparatos S, Velissariou V, Paraskevakou H. Mandibulofacial dysostosis (Treacher-Collins syndrome) in the fetus: Novel association with pectus carinatum in a molecularly confirmed case and review of the fetal phenotype. Birth Defects Res A Clin Mol Teratol. 2013 Nov 29.

Peer reviewed abstracts

1. Tasoulas J, Blumberg J, Schrank S, Sullivan B, Yarbrough W, Sheth S, Hackman Academic programs achieve better thyroid cancer survival, despite longer wait-times. AAO-HNSF Annual Meeting 2023, Nashville TN, September 2023.
2. Tasoulas J, Schrank T, Bharambe H, Johnson S, Divaris K, Theocharis S, Hackman TG, Sheth S, Kirtane K, Hernandez-Prera J, Chung CH, Yarbrough WG, Issaeva N, Amelio AL. Molecular Characterization of the Salivary Adenoid Cystic Carcinoma Tumor Immune Landscape by Anatomic Subsite. ACCRF Meeting, Boston, June 2023
3. Morse RT, Stepp W, Oldan JD, Huang BY, Tasoulas J, Chera BS, Chen X, Hackman T, Shen C. Definitive Chemoradiation Treatment Response Evaluation Using NI-RADS and ctHPVDNA for HPV-Associated Oropharyngeal Squamous Cell Carcinoma. ASTRO: American Society of Therapeutic Radiation and Oncology Annual Meeting 2023.
4. Tasoulas J, Sullivan B, Rehmani H, Kothari A, Issaeva N, Yarbrough WG, Hackman T, Schrank TP. The role of tumor HPV status in survival and treatment response of patients with squamous cell carcinoma of the hypopharynx. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
5. Tasoulas J, Rehmani H, Kothari A, Issaeva N, Yarbrough WG, Schrank TP. AHNS 11th International Conference on Head and Neck Cancer Intra-tumoral copy number variant heterogeneity is common in HPV-positive head and neck squamous cell carcinoma tumors and cell lines. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
6. Tasoulas J, Sewell A, Rehmani H, Rimm D, Anderson KS, Burtness B, Yarbrough WG, Issaeva N. 5-azacytidine promotes immune recognition and T cell infiltration in HPV-positive head and neck squamous cell carcinoma patients. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
7. Stepp W, Tasoulas J, Morse R, Oldan J, Huang B, Shen C, Hackman T. Molecular-based confirmation of the neck imaging reporting and data system (NI-RADS) in the treatment of HPV+ oropharynx cancer. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
8. Cheever R, Tasoulas J, Blumberg J. Outcomes of anterolateral thigh flap, radial forearm flap and pectoralis majorflap in total laryngectomy: a retrospective review. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
9. Farzal Z, Tasoulas J, Hackman T. The International Status of Social Determinants of Health Reporting in Major Head and Neck Cancer Databases. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
10. Sulgi K, Kothari A, Rehmani H, Xue L, Tasoulas J, Schrank TP, Isaeva N, Yarbrough WG. Prognostic Stratification of HPV Associated Head and Neck Squamous Cell Cancer. AHNS 11th International Conference on Head and Neck Cancer, Montreal, Canada, July 2023
11. Tasoulas J, Schrank T, Johnson S, Divaris K, Theocharis S, Hackman TG, Sheth S, Kirtane K, Hernandez-Prera J, Chung CH, Yarbrough WG, Issaeva N, Amelio AL. Molecular Characterization of the Salivary Adenoid Cystic Carcinoma Tumor Immune Landscape by Anatomic Subsite. AHNS/AACR Joint meeting, Montreal, Canada, July 2023
12. Tasoulas J, Isaeva N, Yarbrough WG. Horizontal transfer of functional human papillomavirus genes in head and neck squamous cell carcinoma. AACR Annual Meeting 2023, Orlando, Florida, USA, April 2023
13. Kothari A, Rehmani H, Xue L, Tasoulas J, Sulgi K, Schrank TP, Isaeva N, Yarbrough WG. Novel mouse model to study HPV-associated pathologies. AACR Annual Meeting 2023, Orlando, Florida, USA, April 2023
14. Sulgi K, Kothari A, Rehmani H, Xue L, Tasoulas J, Schrank TP, Isaeva N, Yarbrough WG. Novel mouse model to study HPV-associated pathologies. AACR Annual Meeting 2023, Orlando, Florida, USA, April 2023
15. Musicant AM, Sharma K, Tasoulas J, Amelio AL. The CRTC1/MAML2 oncogene induces a PGC-1a splice variant that sensitizes mucoepidermoid carcinoma cells to PPARg inhibition. AACR Annual Meeting 2019, Atlanta, USA, March 2019
16. Papadiochos I, Tasoulas J, Papadiochou S, Trikka D, Papadogeorgakis N. Patient with herpes zoster involving the maxillary branch at the emergency department: a case report. Congress of the Hellenic Association of Oral and Maxillofacial Surgery – HAOMS2018, Athens, Greece, January 2018.
17. Tasoulas J*, Pantazopoulou V, Giaginis C, Klijanienko J, Theocharis S. Clinical significance of EphA1 and EphA5 expression in human malignant and benign salivary gland tumors, Congress of the European Association of Cranio-Maxillo-Facial Surgery- EACMFS2016, London, UK, September 2016.
18. Tasoulas J*, Papadiochos I, Souliou C, Trikka D, Goutzanis L, Petsinis V, Papadogeorgakis N. Diagnosis and management of severe oculo-orbital injuries from a maxillofacial perspective: a six-year retrospective study, Congress of the European Association of Cranio-Maxillo-Facial Surgery- EACMFS2016, London, UK, September 2016.
19. Papadiochos I*, Sarivalasis S, Tasoulas J, Karekla A, Goutzanis L, Petsinis V, Papadogeorgakis N. Orbital trapdoor fracture in an adult patient: a case report, Congress of the European Association of Cranio-Maxillo-Facial Surgery- EACMFS2016, London, UK, September 2016.
20. Tasoulas J, Daskalopoulos A, Droukas C, Nikitakis NG. An unusual microscopic pattern of foreign body reaction as a complication of dry socket management. American Academy of Oral and Maxillofacial Pathology Meeting, San Diego CA, USA, April 2015
21. Nikitakis NG, Rassidakis G, Tasoulas J, Daskalopoulos A, Kamperos G, Sklavounou A. Assessment of DNA repair mechanisms in oral potentially malignant disorders. Frontiers in Oral Medicine, Joint American Academy of Oral Medicine/ European Academy of Oral Medicine Meeting, Orlando, Florida, USA, April 2014.
22. Kuriakou S, Zanakis S, Tasoulas J, Angelidis I, Dendrinos C. The nasolabial flap in Oral and Maxillofacial Surgery, 29^th National Congress of Oral and Maxillofacial Surgery, Athens, November 2014
23. Zanakis S, Tasoulas J, Kyriakou S, Dendrinos C. Tumors of the soft and hard palate. 39^th National Medical Congress, Athens, May 2013.
24. Zanakis S, Tasoulas J, Kyriakou S, Dendrinos C. Tumors of the neck. 39^th National Medical Congress, Athens, May 2013.
25. Charalambous C, Tasoulas J, Polychronopoulou A, Tzerbos F. Dental extractions in patients under oral anticoagulation therapy. 35^th National Dental Conference, Rhodes, October 2015.
26. Charalambous C, Kouvaratis I., Tasoulas J. Salivaomics technology in diagnosis of Head and Neck Cancer, 14^th Athens Dental School Research Day, Athens, May 2015.
27. Tasoulas J, Charalambous C, Kouvaratis I. Treacher Collins Syndrome: Etiology and Pathogenesis, Athens Dental School Research Day, Athens, May 2013.