American Head & Neck Society

Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient.

Published on by Jon Mallen-St. Clair

Jon Mallen St Clair – Los Angeles, California

Practice Contact Information

Cedars-Sinai Medical Center
8635 West 3rd Street
Suite 590W
Los Angeles
California
90048
United States

Phone: 13104231220
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

I am an assistant professor in the Department of Surgery at Cedars-Sinai with a dual appointment with the Department of Plastic Surgery.

I completed a fellowship in Head and Neck Oncology and Microvascular Reconstructive Surgery at UCSF.  Prior to my fellowship I completed a residency in Otolaryngology – Head and Neck Surgery at UCLA.  I completed medical school in a medical scientist training program at NYU School of medicine.  Prior to that I earned a BA at UC Berkeley.

My clinical practice is focused on reconstructive microsurgery with a focus on mandibular reconstruction. In conjunction with OMFS we have developed one of the few Jaw-in-a-day programs in the United States, offering immediate reconstruction with implants in patients undergoing mandibular reconstruction.

I also have a focus on minimally invasive surgical approaches including the use of transoral robotic surgery for oropharyngeal tumors as well as minimal access approaches to the parotid gland.

Clinical Trials

Bibliography

  1. Bhagwandin V, Hau LW, Mallen-St. Clair J, Wolters PJ, and Caughey GH. Structure and activity of human pancreasin, a novel tryptic protease expressed primarily by the pancreas. J Biol Chem 2003 Jan; 278(5): 3363-3371. PMID: 12441343

 

  1. Mallen-St. Clair J, Pham CTN, Villalta SA, Caughey GH, and Wolters PJ. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 2004 Feb; 113(4): 628-634. PMID: 14966572

 

  1. Wolters PJ, Mallen-St. Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, and Caughey GH. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient KitW-sh/KitW-sh sash mice.  Clin Exp Allergy 2005 Jan; 35(1): 82-8. PMID: 15649271

 

  1. Mallen-St. Clair J, Shi GP, Chapman HA, and Wolters PJ. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol
    2006 Aug; 387(8): 1143-6. PMID: 16895486

 

  1. Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St. Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6): 719-24. PMID: 17546038

 

  1. Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St. Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ. Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem. 2008 Jun; 51(11): 3203-21. PMID: 18465846

 

  1. Connolly MK, Bedrosian AS, Mallen-St Clair J, Mitchell AP, Ibrahim J, Stroud A, Pachter HL, Bar-Sagi D, Frey AB, Miller G.  In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.  J Clin Invest. 2009 Nov; 119(11): 3213-25.  PMID: 19855130

 

  1. Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor.  J Leukoc Biol. 2010 Apr; 87(4): 713-25.  PMID: 20042467

 

  1. Roehm PC, Mallen-St. Clair J, Jethanamest D, Golfinos JG, Shapiro W, Waltzman S, Roland JT Jr. Auditory rehabilitation of patients with neurofibromatosis type 2 by using cochlear implants.  J Neurosurgery. 2011 Oct; 115(4):827-34. PMID: 21761973

 

  1. Mallen-St. Clair J, Soydaner-Azeloglu R, Lee KE, Taylor L, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D. Ezh2 couples pancreatic regeneration to neoplastic progression.  Genes Dev. 2012 Mar 1; 26(5):439-44. PMID: 22391448

 

  1. Mallen-St. Clair J, Arshi A, Tajudeen B, Abemayor E, St. John M. Epidemiology and treatment of lacrimal gland tumors: a population-based cohort analysis.  JAMA Otolaryngol Head Neck Surg. 2014 Dec;140(12):1110-6. PMID: 25393577

 

  1. Fazlollahi F, Kongmanas K, Tanphaichitr N, Mallen-St. Clair J, Gopen Q, Faull K, Suh J. Lipidomic profiling of sinus mucosa from patients with chronic rhinosinusitis. Clin Transl Sci. Apr;8(2):107-15. PMID: 25588779

 

  1. Lin Y, Mallen-St Clair J, Luo J, Sharma S, Dubinett S, St John M. p53 modulates NF-κB mediated epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. Oral Oncol. 2015 Oct;51(10):921-8. PMID: 26306422

 

  1. Maccabi A, Taylor Z, Bajwa N, Mallen-St. Clair J, St. John, M, Sung S, Grundfest W, Saddik, G. An Examination of the Elastic Properties of Tissue-Mimicking Phantoms Using Vibro-Acoustography and a Muscle Motor System. Rev Sci Instrum. 2016 Feb; 87(2):024903. PMID: 26931880

 

  1. Kuan EC, Arshi A, Mallen-St Clair J, Tajudeen BA, Abemayor E, St John MA. Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. Otolaryngology-Head and Neck Surgery 2016 Apr;154(4):667-73. PMID: 26908559

 

  1. Mallen-St. Clair J, Arshi A, Abemayor E, St. John M. Factors Associated with Survival in Patients with Synovial Cell Sarcoma of the Head and Neck: An Analysis of 167 Cases Using the SEER database. JAMA Otolaryngol Head Neck Surg.  2016 April 21. 142(6):576-83. PMID: 27100936

 

  1. Lin Y, Mallen-St Clair J, Palma-Diaz F, Wang G, Luo J, Lai C, Elashoff D, Sharma S, Dubinett S, St John MA. p38 MAPK Mediates Epithelial-Mesenchymal Transition by Regulating p38IP and Snail in Head and Neck Squamous Cell Carcinoma. Oral Oncol. 2016 Sep; 60:81-9. PMID: 27531877

 

  1. Vahabzadeh-Hagh AM, Zipser BD, Tan HT, Hong AY, Mallen-St Clair J, Armin BB. More than Just Tissue Diagnosis in a Patient with Maxillofacial Bony Lesions and Hypercalcemia. Laryngoscope. 2016. Sep 19. PMID: 27641155

 

  1. Kuan EC, Alonso JE, Tajudeen BA, Arshi A, Mallen-St Clair J, St John MA. Small cell carcinoma of the head and neck: A comparative study by primary site based on population data. 2016 Nov 17. PMID: 27859290

 

  1. Han A, Kuan EC, Mallen-St Clair J, Alonso E, Arshi A, St. John M. Epidemiology of Squamous Cell Carcinoma of the Lip in the United States: A Population-Based Cohort  JAMA Otolaryngol Head Neck Surg. 2016 Nov 10. PMID: 27832256

 

  1. Kuan EC, Mallen-St Clair J, Frederick JW, Tajudeen BA, Wang MB, Harvey RJ, Suh JD. Significance of undissected retromaxillary air cells as a risk factor for revision endoscopic sinus surgery.  Am J Rhinol Allergy. 2016 Nov 1;30(6):448-452. PMID: 28124658

 

 

  1. Pellionisz PA, Lin Y, Mallen-St Clair J, Luo J, Suwarnasarn A, Schaue D, Elashoff DA, Palma-Diaz F, Dubinett SM, Sharma S, Wu B, St John MA. Use of a Novel Polymer in an Animal Model of Head and Neck Squamous Cell Carcinoma.  Otolaryngol Head Neck Surg. 2017 Sep 1.  PMID: 28895464

 

  1. Ho AS, Kim S, Tighiouart M, Gudino C, Mita A, Scher KS, Laury A, Prasad R, Shiao SL, Ali N, Patio C, Mallen-St Clair J, Van Eyk JE, Zumsteg ZS. Association of Quantitative Metastatic Lymph Node Burden with Survival in Hypopharyngeal and Laryngeal Cancer. JAMA Oncol. 2017 Nov 30.  PMID: 29192305

 

  1. Alonso JE, Han AY, Kuan EC, Strohl M, Mallen-St Clair J, St. John MA, Ryan WR, Heaton CM. The Survival Impact of Surgical Therapy in Squamous Cell Carcinoma of the Hard Palate.    2018 Feb 5. PMID: 29399797

 

  1. Chan CK, Han AY, Alonso JE, Xu MJ, Mallen-St Clair J, Heaton CM, Ryan WR, Kuan EC, St John MA. Squamous Cell Carcinoma of the Soft Palate in the United States: A Population-Based Study.  Otolaryngol Head Neck Surg.  2018 May 1.  PMID: 29734872

 

  1. Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Mallen-St Clair J, Yoshida EJ, Shiao SL, Leivo I, Zumsteg ZS. Development of a Novel Salivary Gland Cancer Lymph Node Staging System.    2018 May 9.  PMID 29742277

 

  1. Ho AS, Kim S, Tighiouart M, Mita A, Scher KS, Epstein JB, Laury A, Prasad R, Ali N, Patio C, Mallen-St. Clair J, Zumsteg ZS. Quantitative Survival Impact of Composite Treatment Delays in Head and Neck Cancer.  2018 May 9.  PMID 29742280

 

  1. Plonowska KA, Strohl MP, Wang SJ, Ha PK, George JR, Heaton CM, El-Sayed IH, Mallen-St Clair J, Ryan WR. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal disease.  Otolaryngol Head Neck Surg. 2018 Oct 2.  PMID 30274544

 

 

  1. Lu DJ, Luu M, Mita A, Scher K, Shiao SL, Yoshida EP, Sittig MP, Mallen-St Clair J, Ho AS, Zumsteg ZS. Human Papillomavirus-Associated Oropharyngeal Cancer Among Patients Aged 70 and Older: Dramatically Increased Prevalence and Clinical Implications.  Eur J Cancer. 2018 Nov. PMID: 30268920

 

  1. Zumsteg ZS, Luu M, Kim S, Tighiouart M, Mita A, Scher K, Lu DP, Shiao SL, Mallen-St Clair J, Ho AS. Quantitative Lymph Node Burden as a “Very-High Risk” Factor Identifying Head and Neck Cancer Patients Benefiting from Post-Operative Chemoradiation.  Ann Oncol. 2018 Nov 5. PMID: 30395159

 

  1. Han AY, Kuan EC, Mallen-St Clair J, Badran KW, Palma Diaz MF, Blackwell KE, St. John MA. Total Glossectomy with Free Flap Reconstruction: Twenty-Year Experience at a Tertiary Medical Center.  2019 Jan 22. PMID: 30667056

 

  1. Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Yoshida EJ, Mallen-St Clair J, Shiao SL, Leivo I, Zumsteg Z. Survival Impact of Adjuvant Therapy in Salivary Gland Cancers following Resection and Neck Dissection.  Otolaryngol Head Neck Surg. 2019 Feb 5. PMID: 3072113

 

  1. Ho AS, Luu M, Zalt C, Morris LGT, Chen I, Melany M, Ali N, Patio C, Chen Y, Mallen-St Clair J, Braunstein G, Sacks W, Zumsteg ZS. Mortality risk of nonoperative papillary thyroid carcinoma: a corollary for active surveillance.    2019 Aug 13. PMID: 31407637

 

 

  1. Zumsteg ZS, Luu M, Kim S, Tighiouart M, Mita A, Scher KS, Lu DJ, Shiao SL, Mallen-St Clair J, Ho AS. Quantitative lymph node burden as a ‘very-high-risk’ factor identifying head and neck cancer patients benefiting from postoperative chemoradiation. Ann Oncol. 2019 Oct 1;30(10):1669. PMID: 31168574

 

  1. Sittig MP, Luu M, Yoshida EJ, Scher K, Mita A, Shiao SL, Lu DJ, Mallen-St Clair J, Ho AS, Zumsteg ZS. Impact of insurance on survival in patients < 65 with head & neck cancer treated with radiotherapy. Clin Otolaryngol. 2020 Jan;45(1):63-72. PMID: 31661188

 

  1. Lu DJ, Luu M, Nguyen AT, Scher KS, Mallen-St Clair J, Mita A, Shiao SL, Ho AS, Zumsteg ZS. Survival outcomes with concomitant chemoradiotherapy in older adults with oropharyngeal carcinoma in an era of increasing human papillomavirus (HPV) prevalence. Oral Oncol. 2019 Dec; 99:104472. PMID: 31704556

 

  1. Nguyen AT, Luu M, Lu DJ, Hamid O, Mallen-St Clair J, Faries MB, Gharavi NM, Ho AS, Zumsteg ZS. Quantitative metastatic lymph node burden and survival in Merkel cell carcinoma. J Am Acad Dermatol. 2020 Jan 16: S0190-9622(20)30062-1 . PMID: 31954753

 

  1. Sittig MP, Luu M, Yoshida EJ, Sher K, Mita A, Shiao SL, Lu DJ, Mallen-St. Clair J, Ho AS, Zumsteg, Z. Impact of insurance on survival in patients < 65 with head & neck cancer. Clin Otolaryngol. 2020 Jan. PMID 3281602

 

  1. Yoshida EJ, Luu M, Mallen-St Clair J, Mita AC, Scher KS, Lu DJ, Nguyen AT, Shiao SL, Ho AS, Zumsteg ZS Stage I HPV-positive oropharyngeal cancer: Should all patients receive similar treatments? 2020 Jan 1;126(1):58-66. PMID: 31536144

 

  1. Ho AS, Luu M, Barrios L, Chen I, Melany M, Ali N, Patio C, Chen Y, Bose S, Fan X, Mallen-St Clair J, Braunstein GD, Sacks WL, Zumsteg ZS. Incidence and Mortality Risk Spectrum Across Aggressive Variants of Papillary Thyroid Carcinoma. JAMA Oncol. 2020 Mar 5;6(5):1-8. PMID: 32134428

 

  1. Lu DJ, Luu M, Nguyen AT, Shiao SL, Scher K, Mita A, Anderson E, Mallen-St Clair J, Ho AS, Zumsteg ZS. The role of concomitant chemoradiotherapy in AJCC 7th edition T1-2N1 oropharyngeal carcinoma in the human papillomavirus era. Oral Oncol. 2020 Jul 7; 110:104882. PMID: 32650257

 

  1. Yoshida EJ, Luu M, Freeman M, Essner R, Gharavi NM, Shiao SL, Mallen-St Clair J, Hamid O, Ho AS, Zumsteg ZS. The association between facility volume and overall survival in patients with Merkel cell carcinoma. J Surg Oncol. 2020 Aug;122(2):254-262. PMID: 32297324

 

 

  1. Patel H, Saadat N, Ho AS, Mallen-St Clair J. Virtual Surgical Planning for Bisphosphonate-Related Osteonecrosis of the Jaws.  A Valuable Application in Advanced Cases. 2020 Aug 12. PMID 32923286

 

  1. Ho AS, Luu M, Barrios L, Balzer BL, Bose S, Fan X, Walgama E, Mallen-St. Clair J, Alam U, Shaqat I, Van Eyk JE, Maghami EG, Braunstein GD, Sacks WL, Zumsteg ZS. Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma. Ann Surg Oncol. 2020 Aug 17. PMID 32808161

 

  1. Yoshida E, Luu M, Freeman M, Essner R, Gharavi NM, Shiao SL Mallen-St. Clair J, Ho AS, Zumsteg, Z The association between facility volume and overall survival in patients with Merkel cell carcinoma. J Surg Oncol. 2020 Aug. PMID 32297324

 

  1. Nguyen AT, Luu M, Mallen-St. Clair J, Mita AC, Scher KS, Lu DJ, Shaio SL, Ho AS, Zumsteg, Z. Comparison of Survival After Transoral Robotic Surgery in Patients with Early-Stage Oropharyngeal Squamous Cell Carcinoma. JAMA Oncology. 2020 Oct. PMID 32816023

 

  1. Anderson EM, Luu M, Balzer BL, Scher KS, Mita AC, Lu DJ, Shiao SL, Mallen-St. Clair J, Ho AS, Zumsteg, Z. Variations in the Association of Grade with Survival Across the Head and Neck Cancer Landscape. Head Neck. 2020 Dec 10. PMID 3330064

 

  1. Nguyen AT, Luu M, Lu DJ, Hamid O, Mallen-St Clair J, Faries MB, Gharavi NM, Ho AS, Zumsteg ZS. Quantitative Metastatic Lymph Node Burden and Survival in Merkel Cell Carcinoma.  J Am Acad Dermatol. 2021 Feb;84(2):312-320. PMID: 31954753

 

  1. Ho AS, Luu M, Barrios L, Balzer BL, Bose S, Fan X, Walgama E, Mallen-St Clair J, Alam U, Shafqat I, Lin DC, Chen Y, Van Eyk JE, Maghami EG, Braunstein GD, Sacks WL, Zumsteg ZS. Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma. Ann Surg Oncol. 2021 Mar;28(3):1731-1739. PMID: 32808161

 

  1. Barrios L, Shafqat I, Alam U, Ali N, Patio C, Filarski CF, Bankston H, Mallen-St Clair J, Luu M, Zumsteg ZS, Adashek K, Chen Y, Jain M, Braunstein GD, Sacks WL, Ho AS. Incidental Parathyroidectomy in Thyroidectomy and Central Neck Dissection. 2021 May;169(5):1145-1151. PMID: 33446359

 

  1. Ho AS, Luu M, Kim S, Tighiouart M, Mita AC, Scher KS, Mallen-St Clair J, Walgama ES, Lin DC, Nguyen AT, Zumsteg ZS. Nodal Staging Convergence for HPV- and HPV+ Oropharyngeal Carcinoma.  2021 May 15;127(10):1590-1597.  PMID: 33595897

 

  1. Ryan WR, Xu MJ, Ochoa E, Plonowska-Hirschfeld KA, Zebolsky AL, Ha PK, Bewley AF, Mallen-St Clair J, Joshi AS, Coffey CS, Faraji F, MacDonald BV, Houlton JJ, Gobillot TA, Curry JM, Philips R, Hackman TG, Richmon JD, Holcomb AJ, Coughlin AM, Panwar A, Smith RB, Herberg ME, Fakhry C, Cognetti DM. Oncologic Outcomes of Human Papillomavirus-associated Oropharynx Carcinoma Treated with Surgery Alone: A 12-Institution Study of 344 Patients.  2021 Sep 1;127(17):3092-3106.PMID: 33957701

 

  1. Ho AS, Luu M, Shafqat I, Mallen-St Clair J, Chen MM, Chen Y, Jain M, Ali N, Patio C, Filarski CF, Lin DC, Bankston H, Braunstein GD, Sacks WL, Zumsteg ZS. Predictive Impact of Metastatic Lymph Node Burden on Distant Metastasis Across Papillary Thyroid Cancer Variants.  2021 Oct;31(10):1549-1557. PMID: 34470466

 

  1. Maul X, Dincer BC, Wu AW, Thamboo AV, Higgins TS, Scangas GA, Oliveira K, Ho AS, Mallen-St Clair J, Walgama E. A Clinical Decision Analysis for Use of Antibiotic Prophylaxis for Nonabsorbable Nasal Packing.  Otolaryngol Head Neck Surg. 2021 Nov;165(5):647-654.  PMID: 33588621

 

  1. Nguyen AT, Luu M, Nguyen VP, Hamid O, Faries MB, Gharavi NM, Lu DJ, Mallen-St Clair J, Ho AS, Zumsteg ZS. Development and Validation of a Modified Nodal Classification System for Cutaneous Melanoma.  JAMA Surg. 2021 Nov 1;156(11) PMID: 34468697