Practice Contact Information

Tufts Medical Center
Box 850
800 Washington St
Boston
MA
02111
United States

Phone: 6176363030
Email:
Web Site: https://www.tuftsmedicalcenter.org/patient-care-services/departments-and-services/ear-nose-and-throat-ent-otolaryngology/overview

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Areas of surgical specialization

Endocrine Surgery, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

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Biography/Statement

Dr. Miriam O’Leary is an Associate Professor of Otolaryngology — Head & Neck Surgery at Tufts Medical Center since 2009, and is the Chair of the Dr. Elie E. Rebeiz Department of Otolaryngology — Head & Neck Surgery at Tufts Medical Center.  She earned her M.D. at the University of Connecticut.  She completed a residency in Otolaryngology — Head & Neck Surgery at Boston University and a fellowship in Head & Neck Oncologic Surgery and Microvascular Reconstruction at the University of Miami.  Dr. O’Leary cares for patients with benign and malignant tumors of the head and neck, including the mouth, jaw, throat, voice box, and neck, as well as thyroid, parathyroid, salivary glands, and skin cancers of the head and neck.  Dr. O’Leary performs both removal and reconstruction of head and neck tumors.  Her research interests include outcomes after head and neck surgery.  Dr. O’Leary is also an Assistant Clinical Professor of Oral and Maxillofacial Surgery at Tufts Medical Center.

Clinical Trials

1. EA3132 – Phase II Randomized Trial of Radiotherapy with or Without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing

Objective: To evaluate the disease-free survival (DFS) of patients with stage III-IV squamous cell carcinoma of the head and neck (SCCHN) and disruptive p53 mutations after primary surgical resection followed by postoperative radiotherapy (PORT) alone or PORT with concurrent cisplatin

2. EA3163 – Phase II Randomized Trial of Neoadjuvant Chemotherapy Followed by Surgery and Post-Operative Radiation versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a (and Selected T4b) Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC)

Objective: Evaluate the structure preservation rate for patients with locally advanced resectable NPNSCC with or without neoadjuvant therapy; all patients will undergo surgical resection and postoperative standard care.

Evaluate overall survival (OS) for patients with locally advanced resectable NPNSCC with or without neoadjuvant therapy followed by surgical resection and postoperative standard care.

3. EA3161 – A Phase III Randomized Study of Maintenance Nivolumab Versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPSCC

Objective: To assess the efficacy of concurrent definitive therapy followed by nivolumab compared with concurrent definite therapy followed by observation in terms of overall survival (OS)

4. EA3191 – A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High-Risk Features

Objective: To evaluate OS of adjuvant reirradiation plus concurrent pembrolizumab followed by pembrolizumab to complete 12 months total of pembrolizumab to adjuvant reirradiation plus concurrent platinum chemotherapy in high risk HNSCC patients.

S2101: Biomarker Stratified CaboZantinib (NSC#761968) and NivOlumab (NSC#748726) (BiCaZO) – A Phase II Study of Combining Cabozantinib and Nivolumab in Participants with Advanced Solid Tumors (IO Refractory Melanoma or HNSCC) Stratified by Tumor Biomarkers – an immunoMATCH Pilot Study

Bibliography

Cherie-Ann O. Nathan, D. Neil Hayes, Theodore Karrison, Olivier Harismendy, José M. Flores, Tara Moore-Medlin, Everett E. Vokes, J. Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko Grilley-Olson, Terry Day, Maura Gillison, James L. Wade, Lawrence Feldman, Gautam Jha, Mark Kozloff, Miriam O’Leary, Francis P. Worden, Ezra E.W. Cohen; A Randomized Multi-Institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck. Clin Cancer Res 2022; https://doi.org/10.1158/1078-0432.CCR-21-4290

Schmalbach CE, Ow TJ, Choi KY, O’Leary MA, Lin A, Hughley BB, Emerick K, Moore B, Lee NY, Zandberg DP, Wang SJ. AHNS Position Statement on the Use of PD-1 inhibitors for Treatment of Advanced Cutaneous Squamous Cell Carcinoma Head and Neck October 2022.

Rishi R, Farag A, O’Leary M, Finkelman M, Holland N. Racial Disparities in Head and Neck Squamous Cell Carcinoma Staging at Diagnosis. Poster presentation at Bates-Andrews Research Day, Tufts School of Dental Medicine, Boston MA, March 2022.

Soffer J, Nassif S, Von Plate M, Chisholm J, O’Leary M. Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: a population-based analysis. American Journal of Otolaryngology, accepted June 2021.

Degiovanni J C, Kuo C C, Tokarz E L, et al. (April 21, 2021) Not Your Typical Tonsil: Metastatic Merkel Cell Carcinoma or Primary Disease?. Cureus 13(4): e14604

Park D, Jain S, Quay-De La Vallee Z, Huber K, O’Leary M, Farag AM. Influence of smoking history on the perception of radiation-induced dysgeusia/hypogeusia in patients with head and neck cancer. Eur Arch Otorhinolaryngol. 2020 Oct 31. doi: 10.1007/s00405-020-06447-0

O’Leary M, Wang S. Epidemiology and prevention of Cutaneous Cancer. Otolaryngology Clinics of North America 2021; 54(2): 247-257.

Harb J, Shah A, O’Leary M, Rebeiz E. Breast Cancer Metastases to the Paranasal Sinuses Mimicking Inflammatory Sinus Disease. Journal of Craniofacial Surgery July-August 2020; 31(5).

Bishop J, Park DM, Harb J, O’Leary M, Viswanath A, Finkelman M, Magnuson B, Oreadi D. Outcome analysis of non-vascularized bone graft and fibula free flap in reconstruction of the mandible.  Journal of Oral and Maxillofacial Surgery 2019, 77(9)__suppl: e103-104.

O’Leary MA.  Palatal island flap.  Operative Techniques in Otolaryngology. 2019, 30(2): 151-155.

Anderson E, Linendoll N, Heilman CB, Riesenburger RI, O’Leary MA, Arkun K, Nail TJ, Goodman M, Parsons SK.  Schwannoma Formation in Childhood Cancer Survivors Exposed to Low-Dose Total Body Irradiation. Journal of Adolescent and Young Adult Oncology 2019, 8(4): 477-480.

Gutierrez A, Simmonds J, O’Leary M, Scott A. Partial Cricotracheal Resection with Costal Cartilage Reconstruction for Recurrent Metastatic Papillary Thyroid Carcinoma. Poster presentation at the American Academy of Otolaryngology – Head and Neck Surgery 2018 Annual Meeting, Atlanta, Georgia, October 2018.

Gutierrez A, Simmonds J, O’Leary M, Scott A. Partial Cricotracheal Resection with Costal Cartilage Reconstruction for Recurrent Metastatic Papillary Thyroid Carcinoma. Otolaryngology-Head & Neck Surgery 2018; 159(1) suppl p 255.

Aloma A, O’Leary M, Tse J. Cutaneous angiosarcoma in cognito: A case of angiosarcoma arising in rhinophymatous rosacea. Poster presentation at the American Society of Dermatopathology  annual meeting November 2018, Chicago IL

Harb J, O’Leary MA, Rebeiz E.  Breast Cancer Metastasis to the Sinuses.  Otolaryngology – Head and Neck Surgery 2017; 157(1)_suppl p.284.

Kim WS, Kung J, O’Leary MA. Incidental cervical metastasis of papillary thyroid cancer without a thyroid lesion – a case series.  Poster presentation, World Thyroid Congress July 2017.

Heyes R, Taki N, O’Leary M.  “Vagal paraganglioma presenting as a neck mass associated with cough on palpation” Case Reports in Otolaryngology, Volume 2017 (2017), Article ID 7603814.

Shah A, Dagher W, O’Leary M, Wein R. “Squamous Cell Carcinoma Presenting with Trigeminal Anesthesia: An Uncommon Presentation of Head & Neck Cancer with Unknown Primary”. American Journal of Otolaryngology–Head and Neck Medicine and Surgery 2017; 38(2): 153-56.

Tracy J, Mildenhall N, Wein R, O’Leary M. Breast Cancer Metastases to the Head & Neck: Case Series and Literature Review. Ear, Nose & Throat Journal 2017 96(3):E21-E24.

Alzaman N, Pittas AG, O’Leary M, Ceglia L. “Post-thyroidectomy hypocalcemia exacerbated by chyle leak”. Endocrinology, Diabetes and Metabolism Case Reports March 2015.

Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, O’Leary M, Zitsch R, Siegel BA.  Lymphatic Drainage Patterns in Oral Squamous Cell Carcinoma: Findings of the ACOSOG Z0360 (Alliance) Study.  Otolaryngology-Head & Neck Surgery 2015; 152(4):673-77.

Flis DW, Shah AT, Tracy JC, Heilman CB, O’Leary MA. Metastatic breast carcinoma of the jugular foramen: A rare case of Villaret syndrome. Head and Neck. 2015 Jan 14.

Tracy JC, Heilman CB, O’Leary MA. Metastatic Breast Cancer of the Jugular Foramen: A Rare Cause of Villaret’s Syndrome. Journal of Neurological Surgery Part B, Skull Base 2014; 75 – A203.

Tracy J, Merdad M, O’Leary M, Wein R. Nasopharyngeal Carcinoma: An Awareness and Screening Initiative in Boston’s Chinatown. British Journal of Medicine & Medical Research 4(17):  2014

Mosesso K, Von Euw E, O’Leary M, Wein R.  Tracheostomy Management Made Simple for the Head & Neck Cancer Patient.  Provenir Publishing, Spokane WA, 2014.

Farmer RW, Civantos, Myers, Yarbrough, Siegel, O’Leary, Zitsch. Lymphatic Mapping Patterns in Early Oral Squamous Cell Carcinoma   Otolaryngology-Head & Neck Surgery 2013, Vol 149 No 2 suppl p70.

Wein R, O’Leary M. Cancer of the Unknown Primary in Textbook of Complex Surgical Oncology, McGraw-Hill.

Mohan S, Flis DW, O’Leary MA. A case of trigemino-cardiac reflex during infrastructure maxillectomy Otolaryngology-Head & Neck Surgery June 2014 Vol 140 No 6.

Tracy J, Mukand-Cerro I, O’Leary M, Laver N, Wein R. “Bcl-2 Family Gene Expression in Oropharyngeal Squamous Cell Carcinoma”. Cancer and Clinical Oncology Vol 3, No 1, 2014.

Parekh A, Vecchiotti M, O’Leary M, Scott A. Lower island trapezius myocutaneous flap reconstruction of a large neck defect in an infant. International Journal of Pediatric Otorhinolaryngology 76 (2012) 1852-1854.

Scott A, Parekh A, Vecchiotti A, O’Leary M. Regional Flap Reconstruction of a Neck Defect in an Infant. Otolaryngology Head and Neck Surgery 2011: 145(2)_suppl p 142.

O’Leary M. Free Flap Monitoring in Head & Neck Reconstruction. In Kountakis SE (ed) Encyclopedia of Otolaryngology, Head and Neck Surgery, Springer Publishing.

Wein R, O’Leary M. “Chapter 51: Stomatitis.” In Johnson J, Rosen C (ed) Bailey’s Head & Neck Surgery – Otolaryngology, 5^th edn. Lippincott Williams & Wilkins, Philadelphia, 2014, pgs 736-756.

O’Leary M. Book review: Multidisciplinary H&N Reconstruction: a defect-oriented approach.  Head & Neck 2010; 32(10):1431-32.

O’Leary MA, Noordzij JP, Randolph GW. “Surgical Management of Benign Thyroid Disease” in Practical Manual of Thyroid and Parathyroid Disease, ed. Arora A, Tolley N, Tuttle RM.  Blackwell Publishing.

O’Leary MA, Grillone GA.  “Injection laryngoplasty” in Otolaryngologic Clinics of North America 2006; 39(1):43-54.