Practice Contact Information

University of Southern California – Keck Medical Center
1450 San Pablo Street

Los Angeles
California
90033
United States

Phone: 323-442-5790
Email:
Web Site: https://keck.usc.edu/otolaryngology/faculty/Mark-Swanson/

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Mark Swanson, MD is a fellowship trained head and neck surgeon. After completing medical school at the Ohio State University, he entered a residency in Otolaryngology at University of Southern California. He continued his training with a fellowship in cancer and reconstructive surgery at the University of Miami, and returned to USC to join the faculty at Keck Medical Center. His expertise is in treatment of benign and malignant tumors of the mouth, throat, salivary glands, neck, and thyroid gland. He utilizes advanced robotic, organ preservation, and microvascular reconstructive techniques to maximize quality of life after treatment.

Dr. Swanson works in a multi-disciplinary team including surgeons, radiation oncologists, medical oncologists, and speech/swallow therapists to provide complete care for head and neck diseases.

In addition to treating patients, Dr. Swanson has a research interest in oncologic and quality of life outcomes in head and neck cancers. He focuses on swallowing and voice outcomes after cancer treatments, and is working to provide optimal cancer outcomes while preserving unaffected tissues.

Clinical Trials

Head and neck squamous cell cancer related trials

Bibliography

Bertelsen C, Swanson MS, et al. Contrast-Enhanced Ultrasound with Perflubutane for Sentinel Lymph Node Mapping in Cutaneous Melanoma: A Pilot Study. Laryngoscope – In Press

 Swanson MS, Low G, Sinha UK, Kokot N. Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review. Current opinion in otolaryngology & head and neck surgery. April 2017, 25 (2):133-141. [PMID 28106658]

 Swanson MS, Kokot N, Sinha UK. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers. 2016; Feb 19;8(2): 24. [PMID 2907349]

Ouyoung, L.M., M.S. Swanson, B.C. Villegas, et al., ABCLOVE: Voice therapy outcomes for patients with head and neck cancer. Head Neck, 2016. 38 Suppl 1: p. E1810-3. [PMID 26689974]

Swanson MS, Hudson R, Bhandari N, Sinha UK, Maceri DR, Kokot N. Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):723-7. [PMID 26135979]

 Swanson MS, Sinha UK. Rationale for combined blockade of PD-1 and CTLA-4 in Advanced Head and Neck Squamous Cell Cancer – Review of Current Data. Oral Oncology. 2015 Jan; 51(1):12-15. [PMID 25459157]

 Swanson MS, Brown, TN. Laryngotracheal giant cell tumor: case report and literature review. Case reports in Clinical Pathology. 2015; 2(2).  http://dx.doi.org/10.5430/crcp.v2n2p12 [DOI: 10.5430/crcp.v2n2p12]

 Swanson MS, Sinha UK. Diagnosis and Management of Merkel Cell Carcinoma of the Head and Neck: Current Trends and Controversies. Cancers. 2014; 6(3):1256-1266.  [PMID 24978433]

Radhakrishnan V, Swanson MS, Sinha UK. Monoclonal Antibodies as Treatment Modalities in Head and Neck Cancers. AIMS Medical Science, 2015, 2(4): 347-359. [DOI: 10.3934/medsci.2015.4.347]

Practice Contact Information

Sanford Health\Sanford Research, University of South Dakota Department of Surgery
1310 West 22nd Street, Sioux Falls, SD, USA

Sioux Falls
South Dakota
57105
United States

Phone: 605-328-8200
Email: headandneckcancer@sanfordhealth.org
Web Site: https://www.sanfordhealth.org/sioux-falls/services/head-neck-cancer/team

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

My academic and medical training background includes a strong track record of cancer focused research.  My laboratory focuses on the interaction between the immune system and the cancer cells in human papillomavirus driven head and neck cancers.  I also have an active medical practice caring for and treating head and neck cancer patients.  The failure of treatment in some patients and the morbidity associated with treatment motivate me to search for an improved molecular understanding of head and neck cancer through research.  Current treatment for recurrent metastatic head and neck cancer is limited in efficacy with significant side effects.  My recent research is focused on the interaction of the cancer cell, in the context of chemotherapy treatment, with the immune system and surrounding extracellular environment.  I hope to find ways to augment and modulate that interaction to improve response to treatment and to find less toxic therapy options.  Clinical research is also an important component of my role and I am principal investigator on several trials at Sanford Health.  My overall goal is to improve the treatment for head and neck cancer patients to limit morbidity and increase efficacy and I see research and clinical trials as the main way to make progress over the next five years.

Clinical Trials

Thyroid Cancer Collaborative Registry

Understanding Head and Neck Cancer Tissue Repository

Checkmate 358 (BMS)

Merck 689

NCCORP Sponsored Trials (ECOG 0232, RTOG 9507, HN003, HN004)

Bibliography

Landeen KC, Spanos WC, Gromer L. Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. Head Neck. 2018 May 13. doi: 10.1002/hed.25119. [Epub ahead of print] PubMed PMID: 29756397.

Assam JH, Spanos WC. Oral Cavity Reconstruction Outcomes Using a Porcine Urinary Bladder Matrix: A Retrospective Case Series. Wounds. 2018 May;30(5):131-137. PubMed PMID: 29847304.

Assam JH, Spanos WC. Treatment of Peritonsillar Abscess in Immunosuppressed Patients. S D Med. 2017 Jul;70(7):314-316. PubMed PMID: 28806028.

Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016 Apr 26;7(17):24194-207. doi: 10.18632/oncotarget.8254. PubMed PMID: 27013584; PubMed Central PMCID: PMC5029694.