Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient.
Johns Hopkins University School of Medicine, Department of Otolaryngology – Head and Neck Surgery
6420 Rockledge Drive
Suite 4920
BETHESDA
MD
20817
United States
Phone: (310) 896-3332
Email: mydlarz@jhmi.edu
Web Site: https://www.hopkinsmedicine.org/profiles/results/directory/profile/7591928/wojciech-mydlarz
Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon
Thomas Jefferson University
925 Chestnut Street
Philadelphia
PA
19107
United States
Phone: 215 955 6760
Email: joseph.curry@jefferson.edu
Web Site: http://hospitals.jefferson.edu/departments-and-services/otolaryngology-head-and-neck-surgery.html
Head and Neck Surgeon, Reconstructive Head & Neck Surgery
Dr Curry is an associate professor at Thomas Jefferson University and specializes in Head and Neck Cancer and Reconstructive Surgery. He has been in practice at Thomas Jefferson University since 2010. He completed medical school at Georgetown University, and completed his residency in Otolaryngology Head and Neck Surgery at Thomas Jefferson University. He completed a fellowship in Head and Neck Oncologic and Reconstructive Surgery in 2010. Dr Curry specializes in care of patients with head and neck cancer, such a oral cavity, throat and laryngeal cancer. He also performs reconstructive surgery such as free tissue transfer for jaw defects. Dr Curry’s research focuses on the tumor microenvironment of head and neck cancer.
Mount Sinai Hospital
1470 Madison Avenue
3rd Floor
New York
New York
10029
United States
Phone: 2122419410
Email: mike.yao@mountsinai.org
Web Site: http://www.mountsinai.org/profiles/mike-yao
Endocrine Surgery, Head and Neck Surgeon
Dr. Mike Yao is a fellowship trained head and neck surgical oncologist. A graduate of the University of California, Berkeley, Dr. Yao went to Yale University, School of Medicine. He did his residency in Otolaryngology at Stanford University and completed a Head and Neck Surgical Oncology Fellowship at the MD Anderson Cancer Center in Houston, TX.
After completing his fellowship, Dr. Yao joined the faculty at the University of Illinois at Chicago, where he rose to the rank of Associate Professor and served as program director of the residency program. In 2008, he joined the faculty at Stanford University where he specialized in care of patients with melanoma of the head and neck. In 2011, he moved to Westchester County, NY and was in practice at Westchester Medical Center. He joined the practice at Mount Sinai in 2014.
Dr. Yao cares for patients with head and neck cancer. He has a special interest in diseases of the thyroid and parathyroid, melanoma and advanced skin cancers.
Dr. Yao has over 30 publications and been invited to lecture nationally and internationally over 90 times. He has been named to the Best Doctors and America’s Top Doctors numerous times.
The Sinai Robotic Surgery Trial in HPV Positive Oropharyngeal Squamous Cell Carcinoma (SCCA) (SIRS TRIAL). ClinicalTrials.gov Identifier: NCT02072148. In general, patients with Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma (HPVOPC) are curable, young and will live for prolonged periods. They are at high risk for long-term toxicity and mortality from therapy. While the long-term consequences of chemotherapy and surgery for head and neck cancer are relatively constrained, high-dose radiotherapy (RT) and chemoradiotherapy (CRT) substantially impact on local tissues and organ function and result in a significant rate of late mortality and morbidity in patients. Studies are now being designed to reduce the impact of RT and CRT for patients.
Patients with intermediate stage HPV positive oropharyngeal cancer will be screened for poor prognostic features and undergo robotic surgery. Patients in whom pathology demonstrates good prognosis features will then be followed without postoperative radiotherapy. Patients with subsequent recurrence will be treated with either surgery and postoperative radiotherapy or postoperative chemoradiotherapy alone. Patients with poor prognostic features (ECS, LVI, PNI) will receive reduced dose radiotherapy or chemoradiotherapy based on pathology. It is expected that over 50% of patients treated with surgery will have had a curative treatment and will avoid radiation therapy entirely and long-term survival will not be changed by withholding radiation therapy to good prognosis patients after surgery. There are exploratory biomarkers of risk of recurrence that will be collected and studied.
There are currently few trials examining the role of de-escalation using surgery alone in intermediate and early T-stage HPV related disease. New surgical techniques have broadened the range of patients capable of achieving a complete resection and the functional outcomes in such patients are outstanding. Furthermore, the sensitivity of HPVOPC to chemotherapy and radiotherapy raise the possibility that delayed or salvage treatment in early stage patients would be highly effective, would result in similar survival outcomes and radiotherapy could be applied to a much smaller population then current standards call for. Looked at from a different perspective, the need for post-operative radiotherapy in this younger, HPV+ and more functional population has not been validated in clinical trials to date.
The Quarterback Trial: Reduced Dose Radiotherapy for HPV+ Oropharynx Cancer. ClinicalTrials.gov Identifier: NCT01706939. This trial aims to directly compare a reduced radiation dose to the standard of care in HPVOPC for non-inferiority, thus allowing for direct comparison of outcomes between the two groups. The study hypothesis is that LRC and PFS at 3 years for reduced dose CRT are non-inferior to standard dose CRT.
Ho AS, Tsao GJ, Chen FW, Shen T, Kaplan MJ, Colevas AD, Fischbein NJ, Quon A, Le QT, Pinto HA, Fee WE, Sunwoo JB, Sirjani D, Hara W, Yao M. Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence. Cancer 2013 Apr; 119(7).
Yao M, Roebuck JC, Holsinger FC, Myers JN. Elective neck dissection during salvage laryngectomy. American journal of otolaryngology; 26(6).
Agulnik M, Rhee EN, Yao M, Mundt AJ, Feldman LE. Paclitaxel, carboplatin, and concomitant radiotherapy for resected patients with high risk head and neck cancer. Journal of chemotherapy (Florence, Italy) 2005 Apr; 17(2).
Hall CL, Yao M, Hill LL, Owen-Schaub LB. Essential role for hematopoietic Fas ligand (FasL) in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice. Clinical & experimental metastasis 2004; 21(3).
Saeed S, Yao M, Philip B, Blend M. Localizing hyperfunctioning parathyroid tissue: MRI or nuclear study or both?. Clinical imaging; 30(4).
Ho AS, Kaplan MJ, Fee WE, Yao M, Sunwoo JB, Hwang PH. Targeted endoscopic salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma. International forum of allergy & rhinology; 2(2).
Kolokythas A, Schwartz JL, Pytynia KB, Panda S, Yao M, Homann B, Sroussi HY, Epstein JB, Gordon SC, Adami GR. Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users. Oral oncology 2011 Jun; 47(6).
Klasser GD, Epstein JB, Utsman R, Yao M, Nguyen PH. Parotid gland squamous cell carcinoma invading the temporomandibular joint. Journal of the American Dental Association (1939) 2009 Aug; 140(8).
Mohyuddin N, Yao M. Primary intraosseous carcinoma of the anterior maxilla: an unusual case and review of the literature. Ear, nose, & throat journal 2011 May; 90(5).
Rubinstein PG, Lindgren V, Setty S, Yao M, Pytynia KB, Radosevich JA, Kadkol SS, Feldman LE. Durable complete remission induced by cetuximab monotherapy in a patient infected with HIV and diagnosed with recurrent squamous cell carcinoma of the head and neck. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Mar; 29(9).
Yao M, Epstein JB, Modi BJ, Pytynia KB, Mundt AJ, Feldman LE. Current surgical treatment of squamous cell carcinoma of the head and neck. Oral oncology 2007 Mar; 43(3).
Modi BJ, Knab B, Feldman LE, Mundt AJ, Yao M, Pytynia KB, Epstein J. Review of current treatment practices for carcinoma of the head and neck. Expert opinion on pharmacotherapy 2005 Jun; 6(7).
Cabay RJ, Setty S, Schwartz JL, Yao M, Schmidt ML, Gordon SC. Pediatric squamous cell carcinoma arising in an alpha-fetoprotein-producing mature cystic teratoma of the mandible. Pediatric blood & cancer 2009 Jan; 52(1).
Ahuja G, Cuellar S, Choudhry I, Setty S, Yao M, Villano JL. Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy. Onkologie 2008 Mar; 31(3).
Porter Hospital – Centura Health System
2535 South Downing Street, #480
Denver
Colorado
80210
United States
Phone: (303) 778-5658
Email:
Web Site: https://www.centura.org/locations/colorado-head-and-neck-specialists
Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon
Andrew J. Nemechek, MD, FACS is board-certified in otolaryngology-head and neck surgery and is fellowship-trained in advanced head and neck oncologic surgery. Dr. Nemechek serves as the medical director of the head and neck tumor program at Porter Hospital, part of the Centura Health System. His clinical interests include treating patients tumors the oral cavity and throat structures (larynx and pharynx), thyroid and parathyroid glands, salivary organs, and those with HPV-related malignancies. He also treats patients with advanced cutaneous malignancies, including malignant melanoma. Additionally, he has a strong interest in designing healthcare delivery models and shaping system-wide policies vital to improving healthcare delivery across diverse and at-risk populations.
Dr. Nemechek earned his medical degree from Tulane University School of Medicine, where he also completed training in general surgery and otolaryngology. He completed a combined research and clinical fellowship in advanced head and neck oncologic surgery at the University of Texas MD Anderson Cancer Center. Dr. Nemechek was recently awarded his Master of Science degree in healthcare delivery at the Tuck School of Business and The Dartmouth Institute for Health Policy and Clinical Practice at Dartmouth College.
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland
OH
44195
United States
Phone: 216-445-0838
Email:
Web Site: http://www.ccf.org
Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery
Brian B. Burkey MD, MEd, FACS is currently Vice-chairman and Section Head of the Section of Head and Neck Surgery and Oncology at the Cleveland Clinic Head and Neck Institute. He also serves as Medical Director of the Center for Consumer Health Information within the Marketing Institute at the Cleveland Clinic, which is a group of 30 people dedicated to the production of multimedia patient health information for all medical needs of patients and their families. Dr. Burkey came to the Cleveland Clinic after almost twenty years at Vanderbilt University Medical Center, rising to Professor of Otolaryngology and Vice-chairman within that department.
Dr. Burkey finished undergraduate studies at the Johns Hopkins University, before obtaining his medical degree at the University Of Virginia School Of Medicine in 1986. He completed otolaryngology residency training at the University Of Michigan Department Of Otolaryngology and a fellowship in microvascular and facial plastic and reconstructive surgery at the Ohio State University, before launching his career at Vanderbilt. He has been an American Board of Otolaryngology diplomate since 1992, and his practice has an emphasis on head and neck oncologic and microvascular reconstructive surgery. He began co-directing the Vanderbilt fellowship in Head and Neck Oncologic and Microvascular Reconstructive Surgery starting in 1992, one of the early fellowships in microvascular surgery, and has trained over 30 fellows during his career, almost all of whom have positions in academic otolaryngology both nationally and internationally. He has continued this fellowship at the Cleveland Clinic, which is accredited by the American Head and Neck Society..
At Vanderbilt, Dr. Burkey served as residency Program Director for 15 years, which spanned three successful site visits. Dr. Burkey completed a seven-year tenure on the Otolaryngology Residency Review Committee of the ACGME, serving two years as Vice-chairman and two years as Chairman of that body. He then served as a consultant with ACGME-International and helped three programs in Singapore gain initial accreditation. He was on the steering committee which founded the Otolaryngology Program Directors Organization (OPDO), and served on the Executive Council and as President of the Society of University Otolaryngologists (SUO). He has also served as a guest examiner and senior examiner of the American Board of Otolaryngology and has been a member of the Board of Governors and numerous educational committees of the American College of Surgeons.
Dr. Burkey has been an active member of the American Head and Neck Society, serving on many committees and is now Secretary of that organization. He serves on the editorial board of multiple journals in the field of otolaryngology, and has lectured extensively on educational and clinical subjects both nationally and internationally. He has authored over 20 book chapters and 100 peer-reviewed articles on head and neck and reconstructive surgery topics. He has been a leader on several cooperative group studies and been a co-principal investigator of NIH-funded research. He continues to mentor residents and fellows and is hoping to continue innovation within all areas of medical education. He completed his Masters degree in Education with an emphasis on the health professions in the summer of 2014. Dr. Burkey is married to Maureen, his wife of over 35 years, and their daughter Rachel Burkey lives and teaches in Erie, Pennsylvania.
Please see Cleveland Clinic Foundation website
Book chapters
Burkey BB, Sullivan M. “Skin Expansion.” In: Complications in Dermatologic Surgery, Marwali Harahap (ed). Springer-Verlag, pp. 213-222, 1993.
Burkey BB. “Advances in Soft Tissue Reconstruction of the Oral Cavity.” In: Otolaryngology-Head and Neck Surgery Recertification Study Guide, Jack L. Gluckman, M.D. (ed). Kendall/Hunt Publishing Co. Dubuque, Iowa, pp. 271-275, 1998.
Garrett G, Burkey BB. “Management of Malignant and Pre-Malignant Lesions of the Oral Cavity.” In: Office-Based Surgery of the Head and Neck, Vosef Krespi, M.D. (ed). J.D. Lippincott-Raven. Philadelphia, Pennsylvania, pp. 51-60, 1998.
Sniezek J, Burkey BB. “Airway Control and Laryngotracheal Stenosis in Adults.” In: Ballenger’s Otorhinolaryngology Head and Neck Surgery, 16th edition. B.C. Decker Inc. Hamilton, Ontario, Canada, 2001.
Burkey BB, Coleman JR. “Microvascular Flaps.” In: Facial Plastic and Reconstructive Surgery, 2nd edition. I. Papel (ed). Thieme Inc. New York, New York, pp. 567-590, 2002.
Burkey BB. “Issues in Surgical Management.” Section I: Head and Neck , In: Atlas of Cancer., 1st edition. M. Markman (ed). Lippincott, Williams and Wilkins. Philadelphia, Pennsylvania, 2003.
Burkey BB, Chang D. “Ventral Tongue and Floor of Mouth.” In: Oral Cavity Reconstruction. TA Day and DA Girod (eds). Marcel Dekker Inc. New York, New York, 2003.
Lorenz R, Netterville JL, Burkey BB. “Head and Neck.” In: Sabiston Textbook of Surgery, 17th edition. CM Townsend (ed). Elsevier Inc. Philadelphia, Pennsylvania, 2004.
Lorenz R, Netterville JL, Burkey BB. “Head and Neck.” In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 18th edition. CM Townsend (ed). Elsevier Saunders. Philadelphia, Pennsylvania, November 2007.
Burkey BB, Goudy SL, Rohde. “Airway Control and Laryngotracheal Stenosis in Adults” In: Ballenger’s Otorhinolaryngology Head and Neck Surgery, 17th edition. PA Wackym and JB Snow (eds). B. C. Decker, Inc., publication scheduled for December 2008.
Burkey BB, Hunt JP, Zender C. “Reconstruction of Head and Neck Defects.” In: Practical Head and Neck Oncology. Petruzelli GM (ed). Plural Publishing, San Diego, California, September 2008.
Burkey BB. “Issues in Surgical Management.” Section I: Head and Neck , In: Atlas of Cancer., 2nd edition. M. Markman (ed). Springer Verlag. New York, New York, 2008.
Burkey BB. “Neck Mass.” In: Differential Diagnoses in Otolaryngology. Selesnick S and Stewart M (eds). Thieme Publishing, New York, New York, 2011.
Andersen PE, Burkey BB, Friedlander PL. “Parapharyngeal Space Tumor” In: Atlas of Head and Neck Surgery. Cohen JI and Clayman GL (eds.) Elsevier Saunders. Philadelphia, PA, 2011.
Abdelmalak B, Burkey BB. “Special considerations of anesthesia in cancer patients undergoing flap reconstruction” In: Abdelmalak B, Doyle J (Eds), Head and Neck Anesthesia. Springer, 2012.
Lorenz R, Couch ME, Burkey BB. “Head and Neck.” In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 19th edition. CM Townsend (ed). Elsevier Saunders. Philadelphia, Pennsylvania, 2012.
Burkey B. “Free Flap Reconstruction: The Scapula Flap” In: Myers E., Genden E. (Eds.) Masters in Otolaryngology – Head and Neck Surgery: Reconstructive Surgery of the Head and Neck . Wolters Kluwer/Lippincott, Williams and Wilkens. Philadelphia, PA, 2014.
Revenaugh PC, Shipchandler TZ, Burkey BB. “Microvascular and Regional Flaps in Head and Neck Reconstruction” (Chap. 51). In: Facial Plastic and Reconstructive Surgery, 4th edition. Papel et al (Eds.) Thieme Publishing, New York, New York, 2015.
Burkey B, Osborne K. “The Head and Neck Evaluation of a Vocalist” (Chap. 13). In: Sataloff’s Comprehensive Textbook of Otolaryngology-Head & Neck Surgery; Laryngology Section. Sataloff RT, Benninger MS (Eds.) JP Medical Ltd., 2015
Lorenz R, Couch ME, Burkey BB. “Head and Neck.” In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 20th edition. CM Townsend (ed). Elsevier Saunders. Philadelphia, Pennsylvania, 2017.
Peer-reviewed Publications
Burkey BB, Koopman C, Brunberg J. The Use of Biopsy in the Evaluation of Pediatric Nasopharyngeal Masses. International Journal of Pediatric Otolaryngology. 20: 169-79, 1990.
Burkey BB, Hoffman H, Thornton A, McClatchey K, Baker S. Chondrosarcoma of the Head and Neck. Laryngoscope. 100(12):1301-1305, 1990.
Burkey BB, Esclamado R, Morganroth M. The Role of Cricothyroidotomy in Airway Management. Clinics in Chest Medicine. 12:561-571, 1991.
Burkey BB, Omann G, Wolf GT. Intracellular Calcium Changes Associated with In Vitro Lymphokine-Activated Killer Cell Cytotoxicity. Archives of Otolaryngology-Head and Neck Surgery. 117:1281-1286, 1991.
Esclamado R, Burkey BB, Bradford C. The Platysma Myocutaneous Flap. Archives of Otolaryngology-Head
and Neck Surgery. 120:32-35, 1994.
Reiber M, Burkey BB. Intracavernous Carotid Pseudoaneurysm after Blunt Trauma: A Case Report and Discussion. Head and Neck. 16(3):253-58, 1994.
Burkey BB, Ossoff RH. Endoscopy of Nasopharyngeal Cancer. Diagnostic and Therapeutic Endoscopy. 120:32-35, 1994.
Burkey BB. Pharyngoesophageal Reconstruction. Current Opinion in Otolaryngology and Head and Neck Surgery. 3:267-71, 1995.
Weed D, Chongkolwatana C, Kawamura Y, Burkey BB, Netterville JL, Ossoff RH, Zealear D. Reinnervation of the Allograft Larynx in the Rat Laryngeal Transplant Model. Otolaryngology-Head and Neck Surgery. 113:517-29, 1995.
Wanamaker J, Burkey BB. Overview of the Rectus Abdominis Myocutaneous Flap in Head and Neck
Reconstruction. Facial Plastic Surgery. 12(1):45-50, 1996.
Burkey BB, Clymer M. Other Flaps for Head and Neck Use: Temporoparietal Facial Free Flap, Lateral Arm Free Flap, and Others. Facial Plastic Surgery. 12(1):81-89, 1996.
Weed D, Burkey BB. Current Surgical Techniques: New Techniques in Nerve Grafting in the Head and Neck. Current Opinions in Otolaryngology and Head and Neck Surgery. 4:282-288, 1996.
Burkey BB, The Evolving Role of Sensate Flaps in Head and Neck Reconstruction. Current Opinions in Otolaryngology and Head and Neck Surgery. 29(6):949-961, 1996.
Burkey BB, Garrett G. Use of the Laser in the Oral Cavity. Otolaryngologic Clinics of North America. 29(6):949-961, 1996.
Charous S, Stricklin G, Nanney L, Netterville J, Burkey BB. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Head and Neck Squamous Cell Carcinoma. Annals of Otology, Rhinology and Laryngology. 106(4):271-78, 1997.
Speyer M, Burkey BB, Jackson J. The Effects of 13-Cis Retinoic Acid on Squamous Cell Carcinoma Proliferation and Adhesion to Extracellular Matrix Proteins. Laryngoscope. 107:44-48, 1997.
Civantos F, Burkey BB, Lu F, Armstrong W. The Lateral Arm Microvascular Flap in Head and Neck Reconstruction. Archives of Otolaryngology-Head and Neck Surgery. 123(8):830-836, August 1997.
Burkey BB, Coleman J. Current Concepts in Oromandibular Reconstruction. Otolaryngology Clinics of
North America. 30(4):607-630, 1997
Burkey BB, Fortune DS. The Effect of Microvascular Surgery on Resident Training: A Program Director’s Viewpoint. Current Opinions in Otolaryngology-Head and Neck Surgery. 5(4):243-4, 1997.
Burkey BB, Coleman J. The Selection of Rehabilitation Techniques and the Timing of Procedures in Facial Reanimation. Facial Plastic Surgery Clinics of North America. 5(3):279-285, 1997.
Burkey BB, Speyer M, Maciunas R, Fitzpatrick M, Galloway R, Allen G. Sublabial, Transseptal, Trans-
sphenoidal Approach to the Pituitary Region Guided by the ACUSTAR 1 System. Otolaryngology-Head and Neck Surgery. 118:191-4, 1998.
Netterville JL, Coleman S, Smith J, Smith M, Day TA, Burkey BB. The Management of Substernal Goiter. Laryngoscope. 108:1611-1617, 1998.
Burkey BB, Gerek M. The Evaluation and Treatment of CSF Leaks: A Review. Current Opinions in Otolaryngology and Head and Neck Surgery. 6:263-267, 1998.
Netterville JL, Sinard R, Bryant G, Burkey BB. Delayed Metastasis from Midfacial Squamous Carcinomas. Head and Neck. 20: 328-333, 1998.
Correa AJ, Burkey BB. Current Options in Management of Head and Neck Cancer Patients. Medical Clinics of North America. 83(1):235-246, 1999.
Burkey BB, Gerek M, Day TA. Repair of the Persistent Cerebrospinal Fluid Leak with the Radial Forearm Free Fascial Flap. Laryngoscope. 109(6):1003-06, 1999.
Burkey BB. The pectoralis major myocutaneous flap and its role in head and neck reconstruction. Current Opinion Otoloarygol Head Neck Surg 1999;7(4).
Coleman S, Burkey BB, Day TA, Resser J, Netterville JL. Dauer E, Sutinis E. Increasing Use of the Scapula Osteocutaneous Free Flap. Laryngoscope. 110:1419-1424, 2000.
Coleman S, Smith J, Burkey BB, Day TA, Page R, Netterville J, Long-Standing Neck Mass As the Initial
Manifestation of Well-Differentiated Thyroid Carcinoma. Laryngoscope. 110:204-209, 2000.
Day TA, Tarr C, Zealear D, Burkey BB, Sullivan C. Tongue Replantation in an Animal Model. Microsurgery. 20(3):105-8, 2000.
Murphy BA, Cmelak A, Burkey BB, Netterville JL, Shyr Y, Douglas S, Smith W. Topoisomerase I Inhibitors in the Treatment of Head and Neck Cancer. Oncology. 15 (Suppl 8):47-52, 2001.
Murphy BA, Leong T, Burkey BB, Langer C, Forastiere A. Lack of Efficacy of Topotecan in the Treatment of Metastatic or Recurrent Squamous Carcinoma of the Head and Neck: An Eastern Cooperative Group Trial (E3393). American Journal of Clinical Oncology. 24(1): 64-66, 2001.
Coleman SC, Stewart ZA, Day TA, Netterville JL, Burkey B, Pietenpol JA. Analysis of Cell-Cycle Checkpoint Pathways in Head and Neck Cancer Cell Lines: Implications for Therapeutic Strategies. Archives of Otolaryngology-Head And Neck Surgery. 128(2):167-76, 2002.
Teknos TN, Smith JC, Day TA, Netterville JL, Burkey BB. Microvascular Free Tissue Transfer in Reconstructing Skull Base Defects: Lessons Learned. Laryngoscope. 112(10);1871-6, 2002.
Johnson T, Stephen B, Burkey BB, Renewed Popularity of Scapular Osteocutaneous Free Flaps for Complex Head and Neck Reconstruction. Current Opinion in Otolaryngology-Head and Neck Surgery. 10(4): 261-65, 2002.
Hunt P, Burkey BB. Use of Local and Regional Flaps in Modern Head and Neck Reconstruction. Current Opinion in Otolaryngology & Head and Neck Surgery. 10 (4):249-55, 2002.
Goldstein RE, Netterville JL, Burkey BB, Johnson J. Implications of Follicular Neoplasms, Atypia and Lesions Suspicious for Malignancy Diagnoses by Fine-Needle Aspiration of the Thyroid Nodule. Annals of Surgery. 235 (5): 656-64, 2002.
Moore BA, Duncan IM, Burkey BB, Day TA. Incidental Metastatic Papillary Thyroid Carcinoma in Microvascular Reconstruction. Laryngoscope. 112(12):2170-7, 2002.
Sniezek JC, Matheny KE, Burkey BB, Netterville JL, Pietenpol JA. Expressions of p63 and 14-3-3Ф in Normal and Hyperdifferentiated Mucosa of the Upper Aerodigestive Tract. Otolaryngology-Head and Neck Surgery. 126(6):598-601, 2002.
Sabri A, Sniezek J, Burkey BB. Sensate Free Flaps: Operative Techniques. Otolaryngology-Head and Neck
Surgery. 11(3):195-97, 2002.
Sniezek JC, Sabri A, Burkey BB, Barille DJ. Reconstruction After Burns of the Face and Neck. Current Opinions in Otolaryngology and Head and Neck Surgery. 8:277-81, 2002.
Song JK, Burkey BB, Konrad P. Lateral Approach to a Neurenteric Cyst of the Cervical Spine: Case Presentation and Review of Surgical Technique. Journal of Neurosurgery: Spine. 28(4):E81-5, 2003.
Richards SV, Welch DC, Bayles SW, Burkey BB. Alveolar Soft Part Sarcoma of the Mandible. Otolaryngology-Head and Neck Surgery. 128(1): 148-50, 2003.
Moore BA, Magdy E, Netterville JL, Burkey BB. Palatal Reconstruction with the Palatal Island Flap. Laryngoscope. 113(6): 946-51, 2003.
Wax MK, Burkey BB, Bascom DI, Rosenthal EL. The Role of Free Tissue Transfer in the Reconstruction of Massive Neglected Skin Cancers of the Head and Neck. Archives of Facial Plastic Surgery, 5(6):479-82, 2003.
Chang CW, Burkey BB, Netterville JL, Courey MS, Garrett C, Bayles SW. Carbon Dioxide Laser Endoscopic Diverticulectomy Versus Open Diverticulectomy for Zenker’s Diverticulum. Laryngoscope. 114(3):519-27, 2004.
Coppit GL, Lin DT, Burkey BB. Current Concepts in Lip Reconstruction. Current Opinions in Otolaryngology-Head and Neck Surgery. 12(4):281-7, 2004.
Lin DT, Coppit GL, Burkey BB. Use of the Anterolateral Thigh Flap for Reconstruction of the Head and Neck. Current Opinions in Otolaryngology-Head and Neck Surgery. 12(4):300-4, 2004.
Vos JD, Burkey BB. Functional Outcomes After Free Flap Reconstruction of the Upper Aerodigestive Tract. Current Opinions in Otolaryngology-Head and Neck Surgery. 12(4):305-10, 2004.
Lin DT, Coppit GL, Burkey BB, Netterville JL. Tumors of the Accessory Lobe of the Parotid Gland: A 10-year Experience. Laryngoscope. 114(9):1652-5, 2004.
Lin DT, Cohen SM, Coppit GL, Burkey BB. Squamous Cell Carcinoma of the Oropharynx and Hypopharynx. Otolaryngology Clinics of North America. 38(1):59-74, 2005.
Cohen SM, Burkey BB, Netterville JL. Surgical Management of Parapharyngeal Space Masses. Head and Neck. 27(8):669-75, 2005.
Slebos RJ, Yi Y, Ely K, Carter J, Evjen A, Zhang X, Shyr Y, Murphy BM, Cmelak AJ, Burkey BB, Netterville JL, Levy S, Yarbrough WG, Chung CH. Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 12(3 Pt. 1):701-9, 2006.
Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ, Hirsch FR. Increased Epidermal Growth Factor Receptor Gene Copy Number is Associated with Poor Prognosis in Head and Neck Squamous Cell Carcinomas. J Clin Oncol. 24 (25):4170-6, 2006.
Willey CD, Murphy BA, Netterville JL, Burkey BB, Shyr Y, Shakhtour B, Kish B, Raben D, Chen C, Song JI, Kane MA, Cmelak AJ. A Phase II Multi-Institutional Trial of Chemoradiation Using Weekly Docetaxel and Erythropoietin for High-Risk Postoperative Head and Neck Cancer Patients. Int J Radiat Oncol Biol Phys. 67(5):1323-31, 2007.
Cmelak AJ, Murphy BA, Burkey BB, Douglas S, Shyr Y, Netterville JL. Taxane-Based Chemoirradiation for Organ Preservation with Locally Advanced Head and Neck Cancer: Results of a Phase II Multi-Institutional Trial. Head and Neck. 29(4): 315-24, 2007.
Burkey BB. Book Review: Reconstruction of the Cervical Aerodigestive Tract: A Multimedia Atlas by Pierre Delaere, 160 pages, Leuven University Press, Leuven Belgium, 2006. Laryngoscope. 117: March 2007.
Tsue TT, Dugan JW, Burkey B. Assessment of Surgical Competency. Otolaryngologic Clinics of North America. 40(6): 1237-1259, 2007.
Slebos R, Burkey B, Chung C, Gilbert J, Li M, Murphy B, Netterville J, Vadievelu S, Sinard R, Shyr Y, Yarbrough W. Microsatellite Mutations in Buccal Cells from Head and Neck Cancer Patients and Controls. British Journal of Cancer. 98(3): 619-26, 2008.
Gilbert J, Cmelak A, Shyr Y, Netterville J, Burkey BB, Sinard RJ, Yarbrough WG, Chung CH, Aulino JM, Murphy BA. Phase II Trial of Irinotecan Plus Cisplatin in Patients with Recurrent or Metastatic Squamous Carcinoma of the Head and Neck. Cancer 113(1): 186-92, 2008.
Mukherjee K, Cash MP, Burkey BB, Yarbrough WG, Netterville JL, Melvin WV. Antegrade and Retrograde Endoscopy for Treatment of Esophageal Stricture. Am Surg 74(8):686-7, 2008.
Yang ES, Murphy BM, Chung CH, Netterville JL, Burkey BB, Gilbert J, Yarbrough WG, Sinard R, Cmelak AJ. Evolution of Clinical Trials in Head and Neck Cancer. Crit Rev Oncol Hematol Jul; I(1): 29-42, 2009
Moore BA, Wine T, Burkey BB, Amedee RG, Butcher RB II. Sphenoid sinus myxoma: Case report and literature review. The Ochsner Journal 8(4):166-171, 2009.
Moore BA, Burkey BB, Netterville JL, Butcher RB II, Amedee RG. Surgical management of minor salivary gland neoplasms of the palate. The Ochsner Journal 8(4):172-180, 2009.
Britt LD, Sachdeva AK, Healy GB, Whalen TV, Blair PG, Members of ACS Task Force on Resident Duty Hours. Resident duty hours in surgery for ensuring patient safety, providing optimum resident education and training, and promoting resident well-being: a response from the American College of Surgeons to the Report of the Institute of Medicine, “Resident Duty Hours: Enhancing Sleep, Supervision, and Safety”. Surgery. 2009 Sep;146(3):398-409. [PM:19715795]
Kauffman RM, Netterville JL, Burkey BB. Transoral excision of the submandibular gland: techniques and results of nine cases. Laryngoscope 2009 Mar;119(3):502-7. [PM:19235741]
Law JH, Whigham AS, Wirth PS, Liu D, Pham MQ, Vadivelu S, Kirkbride KC, Brown BT, Burkey BB, Sinard RJ, Netterville JL, Yarbrough WG. Human-in-mouse modeling of primary head and neck squamous cell carcinoma. Laryngoscope. 2009 Dec;119(12):2315-23. [PM:19693929]
Kusuma S, Skarupa DJ, Ely KA, Cmelak AJ, Burkey BB. Synovial sarcoma of the head and neck: A review of its diagnosis and management and report of a rare case of orbital involvement. Ear Nose and Throat Journal 2010 Jun;89(6):280-283. [PM:20556741]
Chung DH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J, Burkey BB, Netterville J, Sinard R Yarbrough WG, Cmelak AJ, Slebos RJ, Shyr Y, Parker J, Gilbert J, Murphy BA. Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol. 2010 Apr;21(4):864-870. [PM:19850643]
Murphy BA, Dietrich MS, Wells N, Dwyer K, Ridner SH, Silver HJ, Gilbert J, Chung CH, Cmelak AJ, Burkey B, Yarbrough WG, Sinard R, Netterville J. Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: A tool to assess symptom burden in patients treated with chemoradiation. Head Neck 2010 Jan;32(1):26-37. [PM:19626644]
Jabbour N, Burkey B. Demystifying the ACGME RRC: Your guide to understanding the residency accreditation body. ENT Today 2010 Jul;5(7):20-21.
Rice BL, Farver CF. Pohlman B, Burkey BB, Parambil JG. Concomitant Castleman’s Disease and Sarcoidosis. Am J Med Sci 2011 Mar;341(3):257-9. [PM:21326077]
Chung CH, Pohlmann PR, Rothenberg ML, Burkey BB, Parker J, Palka K, Aulino J, Puzanov I, Murphy B. Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma. Head Neck. 2011 Dec;33(12):1804-1808. [PM:20652976].
Athavale S, Phillips S, Mangus B, Datta J, Sinard R, Netterville J, Burkey B, Yarbrough W. Complications of AlloDerm and DermaMatrix for parotidectomy reconstruction. Head Neck 2012 Jan;34(1):88-93.
Bebek G, Bennett KL, Funchain P, Campbell R, Seth R, Scharpf J, Burkey B, Eng C. Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous cell carcinoma. Human Molecular Genetics 2012;21(7): 1557-1565
Manzoor NF1, Russell JO, Bricker A, Koyfman S, Scharpf J, Burkey B, Khan MJ. Impact of surgical resection on survival in patients with advanced head and neck cancer involving the carotid artery. JAMA Otolaryngol Head Neck Surg. 2013 Nov;139(11):1219-25.
Li M, Milas M, Nasr C, Brainard JA, Khan MJ, Burkey BB, Scharpf J. Anaplastic thyroid cancer in young patients: A contemporary review. Am J Otolaryngol. 2013 Nov-Dec;34(6):636-40.
Li M, Lorenz RR, Khan MJ, Burkey BB, Adelstein DJ, Greskovich JF Jr, Koyfman SA, Scharpf J. Salvage laryngectomy in patients with recurrent laryngeal cancer in the setting of nonoperative treatment failure. Otolaryngol Head Neck Surg. 2013 Aug;149(2):245-51.
Wood JW, Broussard KC, Burkey B. Preoperative testing for radial forearm free flaps to reduce donor site morbidity. JAMA Otolaryngol Head Neck Surg. 2013 Feb;139(2):183-186.
Cooper D, Burkey B, Chute D, Scharpf J. Mammary analogue secretory carcinoma of the soft palate: A report of two cases. Internl J Otolarygol Head Neck Surg. 2013 Sept; 2(5), 174-178.
Jalisi S, Sanan A, McDonough K, Hussein K, Platt M, Truong MT, Couch M, Burkey B. Economic impact of a head and neck oncologic surgeon: The case mix index. Head and Neck. 2014;36(10).
Al-Khudari S, Lorenz R, Burkey BB, Guo S, Greskovich JF, Koyfman SA, Chen Y, Nwizu T, Adelstein DJ. Solitary dural metastasis at presentation in a patient with untreated human papillomavirus-associated squamous cell carcinoma of the oropharynx. Head and Neck. 2014:36(10).
Swegal W, Koyfman S, Greskovich J, Borden E, Scharpf J, Sindwani R, Burkey B. Endoscopic and open surgical approaches to locally advanced sinonasal melanoma: Comparing the therapeutic benefits. JAMA-Otolaryngol Head Neck Surg. 2014;140(9).
Rodriguez C, Adelstein D, Rybicki L, Saxton J, Koyfman S, Greskovich J, Scharpf J, Wood B, Burkey B, Lorenz R, Ives D, Savvides P, Yao M, Lavertu P. Randomized phase III study of 2 cisplatin-based chemoradiation regimens in locally advanced head and neck squamous cell carcinoma: Impact of changing disease epidemiology on contemporary trial design. Head Neck 2015;37(11).
Manyam B, Reddy C, Koyfman S, Gastman B, Zhang A, Vidimos A, Burkey B, Scharpf J, Alam D, Frtiz M. Inferior outcomes in immunosuppressed patients with high-risk cutaneous squamous cell carcinoma of the head and neck treated with surgery and radiation therapy. J Amer Acad Dermatology 2015;73(2).
Trosman S, Lamarre E, Scharpf J, Khan M, Lorenz R, Burkey B, Koyfman S, Ward M, Greskovich J, Al-Khudari S, Nwizu T, Adelstein D. Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy. JAMA-Otolaryngol Head Neck Surg 2015;141(5).
Naik M, Ward M, Kumar A, Saxton J, Greskovich J, Koyfman S, Bledsoe T, Rybicki L, Burkey B, Adelstein D. It is not just IMRT: Human papillomavirus related oropharynx squamous cell carcinoma is associated with better swallowing outcomes after definitive chemoradiotherapy. Oral Oncology 2015;51(8).
Rajasekaran K, Revenaugh P, Benninger M, Burkey B, Sindwani R. Development of a quality care plan to reduce otolaryngologic readmissions. Otolaryngol Head Neck Surg 2015;153(4).
Elegbede A, Rybicki L, Adelstein D, Kaltenbach J, Lorenz R, Schaprf J, Burkey B. Oncologic and functional outcomes of surgical and nonsurgical treatment of advanced squamous cell carcinoma of the supraglottic larynx. JAMA Otologayngol Head Neck Surg 2015;141(12).
Sturgis CD, Burkey BB, Momin S, Hoschar AP. High Grade (Large Cell) Neuroendocrine Carcinoma of the Nasopharynx: Novel Case Report with Touch Preparation Cytology and Positive EBV Encoded Early RNA. Case Rep Pathol. 2015;2015:231070. doi: 10.1155/2015/231070. Epub 2015 May 10.
Woody N, Kofyman S, Xia P, Yu N, Shang Q, Saxton J, Greakovich J, Adelstein D, Nwizy T, Scharpf J, Burkey B. Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV-positive oropharyngeal cancer. Oral Oncology 2016;53.
Noble A, Han J, Greskovich J, Reddy C, Koyfman S, Nwizu T, Adelstein D, Khan M, Scharpf J, Burkey B. Risk factors associated with disease recurrence in patients with stage III/IV squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy. Anticancer Research 2016;36(2).
Bledsoe T, Noble A, Reddy C, Greskovich J, Saxton J, Koyfman S, Burkey B, Nwizu T, Adelstein D. Split-course accelerated hypofractionated radiotherapy: A safe and effective option for head and neck cancer in the elderly or infirm. Anticancer Research 2016;36(3).
Ward M, Reddy C, Greskovich J, Koyfman S, Bhateja P, Nwizu T, Adelstein D, Kmiecik J, Scharpf J, Lamarre E, Burkey B. Impact of feeding tube choice on severe late dysphagia after definitive chemoradiotherapy for human papillomavirus-negative head and neck cancer. Head Neck 2016;38.
Ward M, Houston N, Greskovich J, Koyfman S, Adelstein D, Nwizu T, Bhateja P, Schaprf J, Lamarre E, Lorenz R, Burkey B. Severe late dysphagia and cause of death after concurrent chemoradiation for larynx cancer in patients eligible for RTOG 91-11. Oral Oncology 2016;57.
Ward M, Koyfman S, Joshi N, Woody N, Houston N, Reddy C, Greskovich J, Ross R, Lorenz R, Lamarre E, Scharpf J, Burkey B, Prendes B, Adelstein D. Modern image-guided intensity-modulated radiotherapy for oropharynx cancer and severe late toxic effects: Implications for clinical trial design. JAMA Otolaryngol Head Neck Surg 2016;142(12).
Bhateja P, Ward M, Greskovich J, Reddy C, Koyfman S, Hunter G, Nwizu T, Adelstein D, Lamarre E, Burkey B. Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with radiation alone. Head Neck 2016;38(12).
O’Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W. Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): A multicentre cohort study. Lancet Oncol. 2016 Apr;17(4):440-451. doi: 10.1016/S1470-2045(15)00560-4. Epub 2016 Feb 27.
Russell J, Yan K, Burkey B, Scharpf J. Nonthyroid metastasis to the thyroid gland: Case series and review with observations by primary pathology. Otolaryngol Head Neck Surg 2016;155(6).
Weller M, Ward M, Berriochoa C, Reddy C, Greskovich J, Koyfman S, Trosman S, Burkey BB, Nwizu T, Adelstein D. Predictors of distant metastasis in human papillomavirus-associated oropharyngeal cancer. Head Neck 2017. [Epub ahead of print]
Wang H, Funchain P, Altemus J, Zhang H, Niazi F, Peterson C, Eng C, Burkey B, Lee W, Bebek G. Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas. Genomic Medicine 2017;9(1).
Mukherjee P, Retuerto M, Ghannoum M, Funchain P, Eng C, Burkey B, Fowler N, Jurevic R. Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma. BBA Clinical 2017;7.
Franco MC, Strong AT, Chahal P, Rodriguez J, Veniero J, Elsheikh TM, Burkey BB, Vargo JJ, Bhatt A.
Transgastric Retrograde EUS Sampling of a Mediastinal Mass in a Patient with Radiation Induced Trismus. Endoscopy E-Videos; accepted March 2017.
Ross RB, Koyfman SA, Reddy CA, Houston N, Geiger JL, Woody NM, Joshi NP, Greskovich JF Jr, Burkey BB, Scharpf J, Lamarre ED, Prendes B, Lorenz RR, Adelstein DJ, Ward MC. A matched comparison of human papillomavirus-induced squamous cancer of unknown primary with early oropharynx cancer. Laryngoscope. 2017 Oct 31. doi: 10.1002/lary.26965. [Epub ahead of print]
Foshee CM, Mehdi A, Bierer SB, Traboulsi EI, Isaacson JH, Spencer A, Calabrese C, Burkey BB. A Professionalism Curricular Model to Promote Transformative Learning Among Residents. J Grad Med Educ. 2017 Jun;9(3):351-356. doi: 10.4300/JGME-D-16-00421.1.
Trosman SJ, Bhargavan R, Prendes BL, Burkey BB, Scharpf J. The contemporary utility of intraoperative frozen sections in thyroid surgery. Am J Otolaryngol. 2017 Sep – Oct;38(5):614-617. doi: 10.1016/j.amjoto.2017.07.003. Epub 2017 Jul 5.
Mukherjee PK, Wang H, Retuerto M, Zhang H, Burkey B, Ghannoum MA, Eng C. Bacteriome and mycobiome associations in oral tongue cancer. Oncotarget. 2017 Oct 19;8(57):97273-97289. doi: 10.18632/oncotarget.21921.
Woody NM, Ward MC, Koyfman SA, Reddy CA, Geiger J, Joshi N, Burkey B, Scharpf J, Lamarre E, Prendes B, Adelstein DJ. Adjuvant Chemoradiation After Surgical Resection in Elderly Patients With High-Risk Squamous Cell Carcinoma of the Head and Neck: A National Cancer Database Analysis. Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):784-792. doi: 10.1016/j.ijrobp.2017.03.019. Epub 2017 Mar 18.
Xiao R, Ward MC, Yang K, Adelstein DJ, Koyfman SA, Prendes BL, Burkey BB. Increased pathologic upstaging with rising time to treatment initiation for head and neck cancer: A mechanism for increased mortality. Cancer. 2018 Jan 9. doi: 10.1002/cncr.31213. [Epub ahead of print]
Non-peer-reviewed Publications
Audio-Digest Otolaryngology
Volume 47, Issue 20
October 21, 2014
ISSN 0271-1354
Program Title:
Perspectives in Head and Neck Cancer
Lecture(s) published:
Surgical management of oral cavity cancer in 2014
Audio-Digest Otolaryngology
Volume 48, Issue 21
November 7, 2015
ISSN 0271-1354
Program Title:
Thyroid and Parathyroid Surgery
Lecture(s) published:
Fundamentals of thyroidectomy
Audio-Digest Oncology
Volume 06, Issue 17
September 7, 2015
ISSN 2154-4581
Program Title:
Highlights from the 2015 Multidisciplinary Head and Neck Cancer Update, Part 2
Lecture(s) published:
Surgical management of oral cavity cancer in 2015