Adam Luginbuhl
Thomas Jefferson University
925 Chestnut Street
6th floor
Philadelphia, Pennsylvania 19107
United States
Map It
Email hidden; Javascript is required.
Dr. Luginbuhl is at the cutting edge of research bridging the gap of new immunotheraputic options, radioactive isotopes and surgery to offer a broad array of clinical trials and treatment options for head and neck cancer. His recent work with CDDO compounds in the laboratory have resulted in preventing some of the profound side effects experienced in radiation therapy.
Additionally he is deeply involved in Haitian mission work, taking 3-4 trips/year. He and his partners have performed the first free tissue transfer and continue to operate regularly in 2 different hospitals. He is leading a coalition to bring oncologic care to Haiti through radiation and chemotherapy. https://giving.jefferson.edu/giving/what-to-support/opportunities/complex-head-neck-care-education.html
Dr. Luginbuhl is the principle investigator on multiple trials including:
- Nivolumab +/- Tadalafil Window of Opportunity Trial in Head and neck cancer. 2) Cesium-131 Brachytherapy.
Additional trials involving targeted agents, immunotherapy, radioactive isotopes and metabolic inhibitors.
-
Topf MC, Magaña LC, Salmon K, Hamilton J, Keane WM, Luginbuhl A, Curry JM, Cognetti DM, Boon M, Spiegel JR. Safety and efficacy of functional laryngectomy for end-stage dysphagia. Laryngoscope. 2018 Mar;128(3):597-602. doi: 10.1002/lary.26760. Epub 2017 Jul 17. PubMed PMID: 28714539.
-
2:Curry J, Tassone P, Gill K, Tuluc M, BarAd V, Mollaee M, Whitaker-Menezes D, Rodeck U, Luginbuhl A, Cognetti D, Keane W, Martinez-Outschoorn U. Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma.Otolaryngol Head Neck Surg. 2017 Nov;157(5):798-807. doi: 10.1177/0194599817709224. Epub 2017 Jun 13. PubMed PMID: 28608777.
-
3:Hobelmann K, Luginbuhl A, Bar-Ad V, Keane W, Curry J, Cognetti D. Positron emission tomography/computed tomography after primary transoral robotic surgery for oropharyngeal squamous cell carcinoma. Laryngoscope. 2017 Sep;127(9):2050-2056. doi: 10.1002/lary.26515. Epub 2017 Mar 8. PubMed PMID: 28272799.
-
4:Curry J, Johnson J, Tassone P, Vidal MD, Menezes DW, Sprandio J, Mollaee M, Cotzia P, Birbe R, Lin Z, Gill K, Duddy E, Zhan T, Leiby B, Reyzer M, Cognetti D, Luginbuhl A, Tuluc M, Martinez-Outschoorn U. Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial. Laryngoscope. 2017 Aug;127(8):1808-1815. doi: 10.1002/lary.26489. Epub 2017 Feb 10. PubMed PMID: 28185288; PubMed Central PMCID: PMC5515672.
-
5:Topf MC, Tuluc M, Harshyne LA, Luginbuhl A. Macrophage type 2 differentiation in a patient with laryngeal squamous cell carcinoma and metastatic prostate adenocarcinoma to the cervical lymph nodes. J Immunother Cancer. 2017 Jul 18;5(1):60. doi: 10.1186/s40425-017-0264-z. PubMed PMID: 28716144; PubMed Central PMCID: PMC5514504.
-
6:Mitchell CA, Goldman RA, Curry JM, Cognetti DM, Krein H, Heffelfinger R, Luginbuhl A. Morbidity and Survival in Elderly Patients Undergoing Free Flap Reconstruction: A Retrospective Cohort Study. Otolaryngol Head Neck Surg. 2017 Jul;157(1):42-47. doi: 10.1177/0194599817696301. Epub 2017 Mar 7. PubMed PMID: 28319459.
-
7:Tassone P, Crawley M, Bovenzi C, Zhan T, Keane W, Cognetti D, Luginbuhl A, Curry J. Pathologic Markers in Surgically Treated HPV-Associated Oropharyngeal Cancer: Retrospective Study, Systematic Review, and Meta-analysis. Ann Otol Rhinol Laryngol. 2017 May;126(5):365-374. doi: 10.1177/0003489417693014. Epub 2017 Feb 16. PubMed PMID: 28397563.
-
8:Goodstein L, Galinat L, Curry J, Luginbuhl A, Cognetti D. Sialendoscopy for Sublingual Gland Sialolithiasis. Ann Otol Rhinol Laryngol. 2017 Mar;126(3):216-218. doi: 10.1177/0003489416684846. Epub 2017 Jan 5. PubMed PMID: 28056531.
-
9:Curry JM, Tassone P, Cotzia P, Sprandio J, Luginbuhl A, Cognetti DM, Mollaee M, Domingo M, Pribitkin EA, Keane WM, Zhan TT, Birbe R, Tuluc M, Martinez-Outschoorn U. Multicompartment metabolism in papillary thyroid cancer. Laryngoscope. 2016 Oct;126(10):2410-2418. doi: 10.1002/lary.25799. Epub 2015 Dec 15. PubMed PMID: 26666958; PubMed Central PMCID: PMC4909595.
-
10:Boyce BJ, Curry JM, Luginbuhl A, Cognetti DM. Transoral robotic approach to parapharyngeal space tumors: Case series and technical limitations. Laryngoscope. 2016 Aug;126(8):1776-82. doi: 10.1002/lary.25929. Epub 2016 Mar 24. PubMed PMID: 27010862.
-
11:Balceniuk MD, Wingate NA, Krein H, Curry J, Cognetti D, Heffelfiner R, Luginbuhl A. Effects of a Fibrin Sealant on Skin Graft Tissue Adhesion in a Rodent Model. Otolaryngol Head Neck Surg. 2016 Jul;155(1):76-80. doi: 10.1177/0194599816634616. Epub 2016 Mar 1. PubMed PMID: 26932970.
-
12:Galinat L, Curry J, Luginbuhl A, Rosen D, Cognetti DM. Nonvisualization of Sialoliths during Sialendoscopy. Otolaryngol Head Neck Surg. 2016 Jun;154(6):1019-22. doi: 10.1177/0194599816632165. Epub 2016 Mar 1. PubMed PMID: 26932946.
-
13:D'Souza JN, Luginbuhl AJ, Goldman RA, Heller JE, Curry JM, Cognetti DM. Cervical Spine Spondylodiscitis After Esophageal Dilation in Patients With a History of Laryngectomy or Pharyngectomy and Pharyngeal Irradiation. JAMA Otolaryngol Head Neck Surg. 2016 May 1;142(5):467-71. doi: 10.1001/jamaoto.2015.3038. PubMed PMID: 27010455.
-
14:Gill KS, Tassone P, Hamilton J, Hjelm N, Luginbuhl A, Cognetti D, Tuluc M, Martinez-Outschoorn U, Johnson JM, Curry JM. Thyroid Cancer Metabolism: A Review. J Thyroid Disord Ther. 2016 Feb;5(1). pii: 200. Epub 2016 Jan 14. PubMed PMID: 27213120; PubMed Central PMCID: PMC4874252.
-
15:Languino LR, Singh A, Prisco M, Inman GJ, Luginbuhl A, Curry JM, South AP. Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma. Am J Transl Res. 2016 May 15;8(5):2432-7. eCollection 2016. PubMed PMID: 27347352; PubMed Central PMCID: PMC4891457.
-
16:Johnson JM, Lai SY, Cotzia P, Cognetti D, Luginbuhl A, Pribitkin EA, Zhan T, Mollaee M, Domingo-Vidal M, Chen Y, Campling B, Bar-Ad V, Birbe R, Tuluc M, Martinez Outschoorn U, Curry J. Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer. Semin Oncol. 2015 Dec;42(6):915-22. doi: 10.1053/j.seminoncol.2015.09.025. Epub 2015 Sep 24. PubMed PMID: 26615136; PubMed Central PMCID: PMC4663018.
-
17:Ho S, Luginbuhl A, Finden S, Curry JM, Cognetti DM. Styloid/C1 transverse process juxtaposition as a cause of Eagle's syndrome.Head Neck. 2015 Nov;37(11):E153-6. doi: 10.1002/hed.24024. Epub 2015 Jul 6. PubMed PMID: 25726731.
-
18:Bovenzi CD, Hamilton J, Tassone P, Johnson J, Cognetti DM, Luginbuhl A, Keane WM, Zhan T, Tuluc M, Bar-Ad V, Martinez-Outschoorn U, Curry JM. Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis. Biomed Res Int. 2015;2015:242437. doi: 10.1155/2015/242437. Epub 2015 Dec 8. Review. PubMed PMID: 26779534; PubMed Central PMCID: PMC4686628.
-
19:Bar-Ad V, Palmer J, Yang H, Cognetti D, Curry J, Luginbuhl A, Tuluc M, Campling B, Axelrod R. Current management of locally advanced head and neck cancer: the combination of chemotherapy with locoregional treatments. Semin Oncol. 2014 Dec;41(6):798-806. doi: 10.1053/j.seminoncol.2014.09.018. Epub 2014 Oct 7. Review. PubMed PMID: 25499638.
-
20:Gordin EA, Luginbuhl AL, Ortlip T, Heffelfinger RN, Krein H. Subcutaneous vs intramuscular botulinum toxin: split-face randomized study. JAMA Facial Plast Surg. 2014 May-Jun;16(3):193-8. doi: 10.1001/jamafacial.2013.2458. PubMed PMID: 24699554.
-
21:Curry JM, Sprandio J, Cognetti D, Luginbuhl A, Bar-ad V, Pribitkin E, Tuluc M. Tumor microenvironment in head and neck squamous cell carcinoma. Semin Oncol. 2014 Apr;41(2):217-34. doi: 10.1053/j.seminoncol.2014.03.003. Epub 2014 Mar 5. PubMed PMID: 24787294.
-
22:Nguyen A, Luginbuhl A, Cognetti D, Van Abel K, Bar-Ad V, Intenzo C, Keane W, Curry J. Effectiveness of PET/CT in the preoperative evaluation of neck disease. Laryngoscope. 2014 Jan;124(1):159-64. doi: 10.1002/lary.24329. Epub 2013 Sep 19. PubMed PMID: 23901035.
-
23:Luginbuhl A, Baker A, Curry J, Drejet S, Miller M, Cognetti D. Preoperative cephalometric analysis to predict transoral robotic surgery exposure. J Robot Surg. 2014;8(4):313-7. doi: 10.1007/s11701-014-0471-2. Epub 2014 Jun 24. PubMed PMID: 25419245; PubMed Central PMCID: PMC4236604.
-
24:Luginbuhl A, Modest M, Yan K, Curry J, Heffelfinger R. Novel irradiated axial rotational flap model in the rodent. JAMA Facial Plast Surg. 2013 Sep-Oct;15(5):344-8. doi: 10.1001/jamafacial.2013.963. PubMed PMID: 23787778.
-
25:Cognetti DM, Luginbuhl AJ, Nguyen AL, Curry JM. Early adoption of transoral robotic surgical program: preliminary outcomes.Otolaryngol Head Neck Surg. 2012 Sep;147(3):482-8. doi: 10.1177/0194599812443353. Epub 2012 Apr 10. PubMed PMID: 22496060.
-
26:Luginbuhl A, Schwartz DM, Sestokas AK, Cognetti D, Pribitkin E. Detection of evolving injury to the brachial plexus during transaxillary robotic thyroidectomy. Laryngoscope. 2012 Jan;122(1):110-5. doi: 10.1002/lary.22429. Epub 2011 Nov 17. Review. PubMed PMID: 22095913.
-
27:Ezzat WH, Dahl JP, Luginbuhl A, Gordin E, Krein H, Heffelfinger RN. Recombinant human tissue factor pathway inhibitor prevents thrombosis in a venous tuck model. Laryngoscope. 2010 Nov;120(11):2172-6. doi: 10.1002/lary.20898. PubMed PMID: 20939073.
-
28:Luginbuhl AJ, Pribitkin EA, Krein H, Heffelfinger RN. Assessment of microvascular anastomosis training in otolaryngology residencies: survey of United States program directors. Otolaryngol Head Neck Surg. 2010 Nov;143(5):633-6. doi: 10.1016/j.otohns.2010.08.007. PubMed PMID: 20974331.
-
29:Luginbuhl AJ, Campbell PG, Evans J, Rosen M. Endoscopic repair of high-flow cranial base defects using a bilayer button.Laryngoscope. 2010 May;120(5):876-80. doi: 10.1002/lary.20861. PubMed PMID: 20422679.
-
30:Campbell PG, McGettigan B, Luginbuhl A, Yadla S, Rosen M, Evans JJ. Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas. Neurosurg Focus. 2010 Apr;28(4):E8. doi: 10.3171/2010.1.FOCUS09292. Review. PubMed PMID: 20367365.
-
31:Luginbuhl A, Pribitkin E, Krein H, Heffelfinger R. Assessment of microvascular anastomosis training in otolaryngology residencies: survey of United States program directors. Laryngoscope. 2010;120 Suppl 4:S233. doi: 10.1002/lary.21700. PubMed PMID: 21225831.
-
32:Luginbuhl A, Sanders M, Spiro JD. Prevalence, morphology, and prognosis of human papillomavirus in tonsillar cancer. Ann Otol Rhinol Laryngol. 2009 Oct;118(10):742-9. PubMed PMID: 19894403.
-
33:Burgos JA, Luginbuhl A. Images in clinical medicine. Lymphedema tarda. N Engl J Med. 2009 Mar 5;360(10):1015. doi: 10.1056/NEJMicm053461. PubMed PMID: 19264690.
-
34:Lenzlinger PM, Shimizu S, Marklund N, Thompson HJ, Schwab ME, Saatman KE, Hoover RC, Bareyre FM, Motta M, Luginbuhl A, Pape R, Clouse AK, Morganti-Kossmann C, McIntosh TK. Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. Neuroscience. 2005;134(3):1047-56. PubMed PMID: 15979242.