American Head & Neck Society

Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient.

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Robert Saddawi-Konefka – San Diego California

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Robert Saddawi-Konefka

UC San Diego Health

  • 25
  • 18

3855 Health Sciences Drive
Rm 2343
San Diego, California 92103
United States
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Dr. Saddawi-Konefka is an OHNS resident physician and postdoctoral researcher at UC San Diego. Currently, he is completing an F32-supported fellowship in the laboratory of Dr. Silvio Gutkind at the Moores Cancer Center. Dr. Saddawi-Konefka's research interests include cancer-immune dynamics and the design of translatable, precision immune-oncology therapies for head and neck cancer.

Peer-Reviewed Publications

  1. Saddawi-Konefka, R* et al. Lymphatic-Preserving Treatment Sequencing Unleashes cDC1-Dependent Antitumor Immunity in HNSCC. In press Nat Commun. 2022; 13, 4298 *co-corresponding author
  2. Saddawi-Konefka, R et al. Imaging Biomarkers to Predict Response to Immune Checkpoint Inhibitor Therapy in HNC. In submission
  3. Wu, V., Yung, B., Faraji, F., Saddawi-Konefka, R. et al. A chemogenetic approach reveals a GPCR-Gαs-PKA signaling axis promoting T cell dysfunction and cancer immunotherapy failure. In review Nature Immunology
  4. Gilardi, M., Saddawi-Konefka, R. et al. Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs. Mol Cancer Ther. 2022; 21-0234.
  5. Wang, Z.… Saddawi-Konefka, R* et al. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nat Commun 12, 2383 (2021). *co-corresponding author
  6. Paradis, , Acosta, M., Saddawi-Konefka, R et al. Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. CCR. 2021; 20-3363
  7. Klebaner, D., Saddawi-Konefka, R et al. Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma. 2020; 5, 739–9
  8. Finegersh, A, Moss, WJ, Saddawi‐Konefka, R, et al. Meta‐analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck. Head & Neck. 2020; 1– 9.
  9. Stramiello, J. A., Saddawi-Konefka, R et al. The role of 3D printing in pediatric airway obstruction_ A systematic review. IJPO 2020; 132, 109923
  10. Robert Saddawi-Konefka et al.Transient Abducens Nerve Palsy After SP Block Following Endoscopic Sinus Surgery. JAMA-OHNS, 2019; e1–2 .
  11. Parthasarathy, V., Snyder, B., & Robert Saddawi-Konefka. A Lot to Choke on: Case of Adult Epiglottitis with Concurrent Peritonsillar Abscess in a Patient with a Sore Throat. JEM, 2018; 55 (6), 841–844
  12. Ruth Seelige, Robert Saddawi-Konefka et al. IL-17D and Nrf2 expression protects from MCMV infection. Nature Scientific Reports. 2018; 8, 13670-84
  13. Robert Saddawi-Konefka et al. Expression and Significance of IL-17D and CD163 in Epithelial Ovarian Cancer. J Gyn Obstet 2018; 2 (1:027) .
  14. Brittany N. Burton, Sapideh Gilani, Milli Desai, Robert Saddawi-Konefka et al. Perioperative Risk Factors Associated with Outcomes Following Pediatric Inpatient Sinus Surgery. Annals of Otology, Rhinology & Laryngology 2018; 128, 504-521
  15. Robert Saddawi-Konefka et al. Inverted schneiderian papilloma of the supraglottis: Case report. The Laryngoscope 2017; 5, 96–3.
  16. Robert Saddawi-Konefka et al. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell Reports 2016; 16 (9), 2348–2358.
  17. O’Sullivan T, Robert Saddawi-Konefka et al. Interleukin-17D mediates tumor rejection through recruitment of NK cells. Cell Reports 2014; 7:989-98
  18. Robert Saddawi-Konefka** & T O’Sullivan** et al. Cancer immunoediting by the innate immune system in the absence of adaptive immunity JEM 2012; 209:1869-82 ** co-first author

Reviews and Book Chapters

  1. Robert Saddawi-Konefka*, et al. HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer. The Cancer Journal: The Journal of Principles & Practice of Oncology. 2022; 28, 339-345 *co-corresponding author
  2. Robert Saddawi-Konefka, et al. Defining the Role of Immunotherapy in the Curative Treatment of Locoregionally Advanced Head and Neck Cancer: Promises, Challenges, and Opportunities. Frontiers in Oncology. 2021; 11, 738626
  3. Robert Saddawi-Konefka, Bui JD. Chapter 29: Tumor Antigen Profiling. Cancer Immunotherapy Principles and Practice, 2nd Edition. 2021; 498–510
  4. Robert Saddawi-Konefka, Watson, D. Nonsurgical Treatment of Keloids and Hypertrophic Scars. Facial Plast Surg; 2019 35, 260–266.
  5. Robert Saddawi-Konefka, Bui JD. Chapter 29: Tumor Antigen Profiling. Cancer Immunotherapy Principles and Practice. 2017; 489–502.
  6. Robert Saddawi-Konefka et al. Tumor-expressed IL-17D recruits NK cells to reject tumors. Oncoimmunology 2014; 3:12
  7. Robert Saddawi-Konefka, Crawford, J. R. Chronic viral infection and primary central nervous system malignancy. J NeuroI Pharm 2010; 5:387–403