Fibroblast

Human

Oral mucosa

Non-malignant

Negative

No

No

Orthotopic

Primary cancer-associated and normal oral fibroblasts

Yes

Wheeler SE, Shi H, Lin F, Dasari S, Bednash J, Thorne S, Watkins S, Joshi R, Thomas SM. Tumor associated fibroblasts enhance head and neck squamous cell carcinoma proliferation, invasion and metastasis in preclinical models. Head & Neck, 2013, 35. PMCID: PMC4111913.

Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, Dasari S, Gutierrez W, Leef G, Ponnurangam S, Chavan H, Ganaden L, Thornton M, Dai H, Tawfik O, Straub J, Shnayder Y, Kakarala K, Tsue T, Girod D, Houten B, Shrikant A, Krishnamurthy P and Thomas SM. Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression. Cancer Research, 2018, 78(14):3769-3782. PMID: 29769197 PMCID: PMC6050074